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Single dose-group A

Phase 1

Colitis, Ulcerative | Monoclonal antibody | Other |Pfizer, Inc.|Last Updated: Jun 26, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment80
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00928681A Study To Investigate The Safety And Efficacy Properties Of PF-00547659 In Patients With Active Ulcerative ColitisPHASE1 COMPLETED 80Sep 1, 2005Oct 1, 2008Jun 26, 200918 Belgium, Czechia +5
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Study Endpoints
Primary Endpoints
Safety and toleration
up to 12 weeks
Endoscopic score changes as calculated using section 3 of the Mayo Score
up to 12 weeks
Disease activity score changes as calculated using the Mayo Score
up to 12 weeks
Secondary Endpoints
Plasma concentrations of PF-00547659
up to 12 weeks
Fecal concentrations of calprotectin
up to 12 weeks
Plasma concentrations of CRP
up to 12 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
0.03 mg/kg or placebo ivOTHER -
0.1 mg/kg or placebo ivOTHER -
0.3 mg/kg or placebo ivOTHER -
1.0 mg/kg or placebo ivEXPERIMENTAL -
3.0 mg/kg or placebo scOTHER -
10 mg/kg or placebo ivOTHER -
0.3 mg/kg or placebo scOTHER -
0.1 mg/kg or placebo iv (multiple dose)OTHER -
0.3 mg/kg or placebo iv (multiple dose)OTHER -
3.0 mg/kg or placebo ivOTHER -
0.1 mg/kg or placebo scOTHER -
0.3 mg/kg or placebo sc (multiple dose)OTHER -
Interventions
NameTypeDescription
Single dose-group ABIOLOGICALPF-00547659, single iv dose
Multiple dose- Group BBIOLOGICALPF-00547659, multiple dose
Multiple dose-Group BBIOLOGICALPF-00547659, multiple dose
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Eligibility Criteria
Age Range18 Years — 70 Years
SexALL
Healthy VolunteersNo
Study Sites18

Inclusion Criteria: * A positive histological diagnosis of UC ≥3 months prior to entry into the study. If a histological diagnosis is not available but all signs and symptoms suggest UC, the subject's eligibility should be discussed with Pfizer. * Active UC as defined by a score of ≥6 on the Mayo s...

Countries:BelgiumCzechiaDenmarkGermanyNorwaySlovakiaSpain
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