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SGN-75

Phase 1

Carcinoma, Renal Cell | Small molecule | Oncology |Pfizer, Inc.|Last Updated: Dec 18, 2014

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment58

FDA Designations

No designations recorded

Clinical trial landscape

SGN-75 · 1 trial · 2 indications

Phase 1 1
NCT01015911A Phase 1 Dose-escalation Trial of SGN-75 in CD70-positive Non-Hodgkin Lymphoma or Renal Cell CarcinomaCarcinoma, Renal Cell
COMPLETED58 Analytics
PHASE1COMPLETED
A Phase 1 Dose-escalation Trial of SGN-75 in CD70-positive Non-Hodgkin Lymphoma or Renal Cell Carcinoma
Carcinoma, Renal CellUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of adverse events and laboratory abnormalities
Through 1 month following last dose

Secondary Endpoints

Best clinical response
Every 2 months
Duration of response, progression-free survival
Every 3 months until progression of disease or initiation of new treatment for cancer
Blood concentrations of SGN-75 and metabolites
Through 1 month following last dose
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTALSGN-75

Interventions

NameTypeDescription
SGN-75DRUGSGN-75 (IV) in 21- or 28-day cycles; dose range: 0.3-9 mg/kg
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites9

Inclusion Criteria: * Pathologically-confirmed diagnosis of NHL or RCC * Relapsed, refractory, or progressive disease following at least 1 prior systemic therapy * Confirmed CD70 expression * Measurable disease, defined as at least 1 lesion \>1.5 cm in the greatest transverse diameter for patients ...

Countries:United States
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Frequently asked questions about SGN-75

What is SGN-75 used for?

SGN-75 is an investigational small molecule being studied for the treatment of renal cell carcinoma and CD70-positive non-Hodgkin lymphoma. It is in Phase 1 clinical development and is not yet approved by the FDA.

Who makes SGN-75?

SGN-75 is being developed by Pfizer, Inc., which trades under the ticker symbol PFE. The drug is currently in Phase 1 clinical trials.

What phase is SGN-75 in?

SGN-75 is in Phase 1 clinical development. It has completed one Phase 1 trial and is not yet approved by the FDA.

What clinical trials is SGN-75 in?

SGN-75 has one completed clinical trial, NCT01015911, which was a Phase 1 dose-escalation study in CD70-positive non-Hodgkin lymphoma or renal cell carcinoma. The trial enrolled 58 participants in the United States.

Is SGN-75 FDA approved?

SGN-75 is not FDA approved. It is an investigational drug that has completed a Phase 1 clinical trial and remains in clinical development.