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SBI-087

Phase 2

Active Rheumatoid Arthritis | Small molecule | Immunology |Pfizer, Inc.|Last Updated: Dec 3, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment210
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01008852Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid ArthritisPHASE2 COMPLETED 210Dec 1, 2009Jul 1, 2013Dec 3, 201355 United States, Argentina +8
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Study Endpoints
Primary Endpoints
Response as measured by American College of Rheumatology criteria (ACR 20 response)
16 weeks
Secondary Endpoints
ACR Responses, 28 Joint Assessment, Pain Visual Analog Scale (VAS), General Health VAS, Physician and Patient Global Assessments, Morning Stiffness Duration, FACIT-Fatigue, SF-36, HAQ-DI, Hybrid Measure of ACR, ACR-N, DAS-28 and EULAR response
up to 24 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Treatment Group 1EXPERIMENTAL -
Treatment Group 2EXPERIMENTAL -
Treatment Group 3EXPERIMENTAL -
Treatment Group 4EXPERIMENTAL -
Treatment Group 5PLACEBO_COMPARATOR -
Interventions
NameTypeDescription
SBI-087DRUG200 mg SC Day 1, Placebo Day 15, Placebo Day 84 + Methotrexate
PlaceboDRUGPlacebo Day 1, Placebo Day 15, Placebo Day 84 + Methotrexate
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites55

Inclusion Criteria: * Meets the American College of Rheumatology (ACR) 1987 revised criteria for classification of Rheumatoid Arthritis (RA) for at least 6 months prior to screening * Active RA as defined by \>= 5 swollen and \>= 5 tender joints (28-joint count) and at least 1 of the following: C-r...

Countries:United StatesArgentinaCanadaChileHungaryJapanMexicoPolandSerbiaSpain
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