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Also known as Prototype (AN0128 Toothpaste)
Prototype · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| Negative Control | PLACEBO_COMPARATOR | Regular Toothpaste |
| Positive Control | ACTIVE_COMPARATOR | Standard anti-plaque and anti-bacterial toothpaste. |
| Prototype | ACTIVE_COMPARATOR | AN0128 Toothpaste |
| Name | Type | Description |
|---|---|---|
| Negative Control (Regular Toothpaste) | OTHER | Regular Toothpaste |
| Positive Control (anti-plaque/anti-bacterial toothpaste) | OTHER | Standard anti-plaque and anti-bacterial toothpaste |
| Prototype (AN0128 Toothpaste) | DRUG | AN0128 Toothpaste |
Inclusion Criteria: * Must be between ages 18 to 65 years inclusive * Have a minimum of 16 natural uncrowned teeth (excluding 3rd molars) present * Must give written informed consent * Be in good general health * Must discontinue oral hygiene for 24-hours after initial appointment * No known histor...
Prototype is an investigational small molecule developed for dental plaque. It was studied as a toothpaste formulation in a Phase 1 trial in healthy adult volunteers. It is not an approved product and remains in clinical development for its intended use in dental plaque.
Prototype is developed by Pfizer, Inc., which trades on the New York Stock Exchange under the ticker PFE. Pfizer sponsored the clinical research evaluating the anti-plaque effect of the AN0128 toothpaste formulation in healthy adult volunteers.
Prototype is in Phase 1 clinical development. One Phase 1 trial has been completed, and no active trials are currently listed. The program has not advanced beyond early-stage testing, and Prototype is investigational rather than an approved therapy.
Prototype has been evaluated in one completed Phase 1 trial, NCT00762151, titled A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste. The trial enrolled 18 healthy adult volunteers in the United States, used a placebo control, and was conducted in participants aged 18 years and older.
Yes. Prototype is also known as AN0128 Toothpaste, and the two names refer to the same investigational product. The completed Phase 1 study NCT00762151 was conducted under the AN0128 Toothpaste designation, evaluating its anti-plaque effect in healthy adult volunteers.