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Premarin/MPA formulation A

Phase 1

Menopause | Small molecule | Other |Pfizer, Inc.|Last Updated: Feb 4, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment76
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00630435Study Comparing 3 New Formulations of Premarin® 0.625 mg/MPA 2.5 mg With a Reference FormulationPHASE1 COMPLETED 76Feb 1, 2008Jun 1, 2008Feb 4, 2009 -
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Study Endpoints
Primary Endpoints
Plasma concentrations of Premarin® and medroxyprogesterone acetate between test and currently marketed formulations
14 weeks
Secondary Endpoints
No secondary outcome
No time frame
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2EXPERIMENTAL -
3EXPERIMENTAL -
4ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Premarin®/MPA formulation ADRUG -
Premarin®/MPA formulation BDRUG -
Premarin®/MPA formulation CDRUG -
Premarin®/MPA currently marketed productDRUG -
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Eligibility Criteria
Age Range35 Years — 70 Years
SexFEMALE
Healthy VolunteersYes

Inclusion 1. Healthy postmenopausal women aged 35 to 70. 2. Body mass index of 18 to 35 kg/m2, weight must be at least 50 kg. 3. Nonsmoker or smoker of fewer than 10 cigarettes/day. Exclusion 1. History or presence of hypertension (\>139 mm Hg systolic or \>89 mm Hg diastolic). Can take up to 2 a...

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