Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771 · 1 trial · 1 indication
Area under the plasma concentration time-curve from zero to the last measured concentration (AUClast)
| Arm | Type | Description |
|---|---|---|
| Active tratment | EXPERIMENTAL | Pravastatin, midazolam, losartan, omeprazole, caffeine single dose alone or in combination with PF-05089771 |
| Name | Type | Description |
|---|---|---|
| Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771 | DRUG | PF-05089771 450mg single dose and titration from 150mg BID to 450mg BID Pravastatin 10mg dingle dose, Midazolam 7.5mg single dose, Losartan 25mg single dose, Caffeine 100mg single dose, Omeprazole 20mg single dose |
Inclusion Criteria: * Healthy male and/or female subjects between the ages of 18 and 55 years; * Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs); Exclusion Criteria: * Any condition possibly affecting drug absorption * History of regular alcohol consumption ...