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Also known as Phenytoin (Ascoli)
Phenytoin · 2 trials · 1 indication
| Arm | Type | Description |
|---|---|---|
| Phenytoin manufactured at Vega Baja site | ACTIVE_COMPARATOR | - |
| Phenytoin manufactored at Ascoli site | EXPERIMENTAL | - |
| Phenytoin | EXPERIMENTAL | - |
| Epamin | ACTIVE_COMPARATOR | - |
| Name | Type | Description |
|---|---|---|
| Phenytoin (Ascoli) | DRUG | Phenytoin 50mg chewable tablets |
| Phenytoin (Vega Baja) | DRUG | Phenytoin 50mg chewable tablets |
| Phenytoin | DRUG | Single dose of Phenytoin 125 mg/5 ml suspension made by Laboratorios Pfizer, S.A. de C.V. |
| Epamin | DRUG | Single dose Epamin 125 mg/5 ml suspension made by McNeil LA LLC |
Inclusion Criteria: 1. Healthy male participants and female participants of non-childbearing potential aged 18 years or older determined by medical evaluation including detailed medical history, complete physical examination, blood pressure (BP) and pulse rate measurement, 12-lead electrocardiogram...
Phenytoin is a small molecule drug developed by Pfizer, Inc. (ticker: PFE). It is currently in Phase 1 clinical development. The specific medical conditions it is being studied for have not been disclosed. Phenytoin is also known as Phenytoin (Ascoli).
Phenytoin targets several sodium channel proteins: SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, and SCN9A. It acts as a blocker of these targets. This mechanism of action is based on its molecular target profile.
Phenytoin is developed by Pfizer, Inc., which trades under the ticker symbol PFE. Pfizer is the company responsible for the clinical development of this drug candidate.
Phenytoin is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The Phase 1 trials are designed to study its pharmacokinetics and bioequivalence in healthy volunteers.
Phenytoin has been studied in two completed Phase 1 clinical trials: NCT06466473 and NCT01122953. NCT06466473 enrolled 35 healthy adults in the United States to study how different forms of phenytoin are absorbed. NCT01122953 enrolled 34 healthy volunteers in Mexico to compare the bioequivalence of Pfizer's phenytoin suspension with Epamin.
Yes, Phenytoin is also known as Phenytoin (Ascoli). Both names refer to the same drug candidate developed by Pfizer, Inc. (ticker: PFE).