Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Also known as pantoprazole for approximately 9 weeks.
Pantoprazole for approximately 9 weeks · 2 trials · 2 indications
AUC (0-t)= Area under the plasma concentration versus time curve from time zero (predose) to time of last quantifiable concentration (0-t).
AUC (0 - ∞)= Area under the plasma concentration versus time curve (AUC) from time zero (predose) to extrapolated infinite time (0 - ∞). It is obtained from AUC (0 - t) plus AUC (t - ∞).
Plasma decay half-life is the time measured for the plasma concentration to decrease by one half.
Clearance of a drug is a measure of the rate at which a drug is metabolized or eliminated by normal biological processes. Clearance obtained after oral dose (apparent oral clearance) is influenced by the fraction of the dose absorbed. Clearance was estimated from population pharmacokinetic (PK) modeling. Drug clearance is a quantitative measure of the rate at which a drug substance is removed from the blood.
Vz/F was calculated as the ratio of clearance (CL) to terminal disposition rate constant (λz).
| Name | Type | Description |
|---|---|---|
| pantoprazole for approximately 9 weeks. | DRUG | - |
| Pantoprazole for approximately 9 weeks | DRUG | - |
Inclusion Criteria: * Endoscopically proven GERD diagnosed within 6 months before study entry. * Weight must be equal to or over 8.3 kg; for subjects 6 years or greater, weight must be equal to or under 25 kg Exclusion Criteria: * History of GI disorders, ie, unrepaired tracheal esophageal fistul...