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PF-07940369

Phase 1

Healthy | Small molecule | Other |Pfizer, Inc.|Last Updated: Apr 7, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment22

FDA Designations

No designations recorded

Clinical trial landscape

PF-07940369 · 2 trials · 2 indications

Phase 1 2
NCT07514156A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.Healthy Adults
COMPLETED30 Analytics
NCT06532383A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.Healthy
COMPLETED22 Analytics
PHASE1COMPLETED
A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.
Healthy AdultsUnlock trial analytics
PHASE1COMPLETED
A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants With Treatment Emergent Adverse Events (AEs)
Baseline (Day 0) up to 35 days after last dose of study drug
Number of Participants With Treatment Emergent Treatment-Related Adverse Events (AEs)
Baseline (Day 0) up to 35 days after last dose of study medication
Number of Participants With Clinically Significant Change From Baseline in Laboratory Abnormalities
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Vital Signs
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Telemetry Findings
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Electrocardiogram (ECG) Findings
Baseline up to Day 4

Secondary Endpoints

Maximum Observed Plasma Concentration (Cmax) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
Time to Reach Maximum Observed Plasma Concentration (Tmax) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Cohort 1, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
Cohort 2, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
Cohort 3, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
PF-07940369 and Placebo (Cohort 1)EXPERIMENTALSingle dose administration of PF-07940369 and placebo; Within a cohort, participants will receive up to 4 oral doses of PF-07940369 and up to 2 doses of placebo.
PF-07940369 and Placebo (Cohort 2)PLACEBO_COMPARATORSingle dose administration of PF-07940369 and placebo; Within a cohort, participants will receive up to 4 oral doses of PF-07940369 and up to 2 doses of placebo.

Interventions

NameTypeDescription
PF-07940369DRUGOral Tablets
PlaceboDRUGOral Tablets
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male participants and female participants who are not of childbearing potential who are overtly healthy as determine by medical evaluation including medical history, physical examination, laboratory tests, and standard 12 lead electrocardiogram (ECG). * Body mass index (BMI) o...

Countries:Belgium
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Frequently asked questions about PF-07940369

What is PF-07940369?

PF-07940369 is an investigational small molecule being developed by Pfizer, Inc. (PFE). It is currently in Phase 1 clinical development, studied in healthy adults to evaluate how different amounts of the medicine are tolerated and act in the body.

What is PF-07940369 used for?

PF-07940369 is being studied for use in healthy adults. The clinical trials aim to learn how different amounts of the study medicine are tolerated and how it acts in the body. It is not approved for any condition and remains in clinical development.

Who makes PF-07940369?

PF-07940369 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker PFE. The company is conducting Phase 1 clinical trials of this investigational small molecule in healthy adults.

What phase is PF-07940369 in?

PF-07940369 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. Two Phase 1 trials have been completed, both studying the drug in healthy adults to assess tolerability and pharmacokinetics.

What clinical trials is PF-07940369 in?

PF-07940369 has been studied in two completed Phase 1 clinical trials: NCT06532383 and NCT07514156. Both trials were conducted in Belgium, enrolled healthy adults aged 18 years and older, and were randomized, double-blind, and placebo-controlled.

Is PF-07940369 the same as any other drug?

PF-07940369 is not known to be the same as any other drug. It is a distinct investigational small molecule developed by Pfizer. No alternative names have been reported for this compound in the clinical trial information.