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PF-07940369

Phase 1

Undisclosed | Small molecule | Other |Pfizer, Inc.|Trials Updated: Apr 7, 2026

PF-07940369 development status

Highest phase Phase 1
Registered trials 2 across 1 sponsor since Aug 2024

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment52

FDA Designations

No designations recorded

PF-07940369 clinical trials

PF-07940369 · 2 trials · 2 indications

Phase 1 2
NCT07514156A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.Healthy Adults
COMPLETED30 Analytics
NCT06532383A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.Healthy
COMPLETED22 Analytics
PHASE1COMPLETED
A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.
Healthy AdultsUnlock trial analytics
PHASE1COMPLETED
A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 Are Tolerated and Act in the Body in Healthy Adults.
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants With Treatment Emergent Adverse Events (AEs)
Baseline (Day 0) up to 35 days after last dose of study drug
Number of Participants With Treatment Emergent Treatment-Related Adverse Events (AEs)
Baseline (Day 0) up to 35 days after last dose of study medication
Number of Participants With Clinically Significant Change From Baseline in Laboratory Abnormalities
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Vital Signs
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Telemetry Findings
Baseline up to Day 4
Number of Participants With Clinically Significant Change From Baseline in Electrocardiogram (ECG) Findings
Baseline up to Day 4

Secondary Endpoints

Maximum Observed Plasma Concentration (Cmax) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
Time to Reach Maximum Observed Plasma Concentration (Tmax) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of PF-07940369
Pre-dose (0), 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Cohort 1, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
Cohort 2, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
Cohort 3, PF-07940369 or PlaceboEXPERIMENTALMultiple oral dosing
PF-07940369 and Placebo (Cohort 1)EXPERIMENTALSingle dose administration of PF-07940369 and placebo; Within a cohort, participants will receive up to 4 oral doses of PF-07940369 and up to 2 doses of placebo.
PF-07940369 and Placebo (Cohort 2)PLACEBO_COMPARATORSingle dose administration of PF-07940369 and placebo; Within a cohort, participants will receive up to 4 oral doses of PF-07940369 and up to 2 doses of placebo.

Interventions

NameTypeDescription
PF-07940369DRUGOral Tablets
PlaceboDRUGOral Tablets
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male participants and female participants who are not of childbearing potential who are overtly healthy as determine by medical evaluation including medical history, physical examination, laboratory tests, and standard 12 lead electrocardiogram (ECG). * Body mass index (BMI) o...

Countries:Belgium
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Frequently asked questions about PF-07940369

What is PF-07940369?

PF-07940369 is an investigational small molecule developed by Pfizer, Inc. (ticker PFE). It is in Phase 1 clinical development, and the specific disease or condition it is intended to treat has not been disclosed. Two Phase 1 trials in healthy adult volunteers have been completed.

Who makes PF-07940369?

PF-07940369 is being developed by Pfizer, Inc., which trades under the ticker PFE. Pfizer sponsored both of the completed Phase 1 studies of the compound, which were conducted in Belgium.

What phase is PF-07940369 in?

PF-07940369 is in Phase 1 clinical development. Two Phase 1 trials have been completed, and no active trials are currently listed. The compound is investigational and has not been approved by the FDA for any indication.

What clinical trials is PF-07940369 in?

PF-07940369 has been studied in two completed Phase 1 trials: NCT07514156, which enrolled 30 healthy adults, and NCT06532383, which enrolled 22 healthy adults. Both were conducted in Belgium and together enrolled 52 participants.

How were the PF-07940369 Phase 1 trials designed?

Both PF-07940369 Phase 1 trials were randomized, double-blind, and placebo-controlled studies in healthy adult volunteers aged 18 and older. NCT07514156 enrolled 30 participants and NCT06532383 enrolled 22, for a combined total of 52 participants across the two completed studies.