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PF-06700841 Immediate release

Phase 1

Undisclosed | Small molecule | Other |Pfizer, Inc.|Trials Updated: May 9, 2019

PF-06700841 Immediate release target and mechanism

ModalitySmall molecule

Also known as PF-06700841 Immediate release tablets

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment8

FDA Designations

No designations recorded

PF-06700841 Immediate release clinical trials

PF-06700841 Immediate release · 1 trial · 1 indication

Phase 1 1
NCT03765554Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different FormulationsHealthy Participants
COMPLETED8 Analytics
PHASE1COMPLETED
Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulations
Healthy ParticipantsUnlock trial analytics

Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Area under the plasma concentration-time curve from time zero to the last measured concentration (AUClast) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Time to reach maximum observed plasma concentration (Tmax) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Area under the plasma concentration-time curve from time zero to extrapolated infinite time (AUCinf) of PF-06700841 if data permit
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose

Secondary Endpoints

Change from baseline in 12-Lead Electrocardiogram (ECG) parameters - PR interval, QRS complex, QT interval and QTC interval
Pre-dose and 48 hours post-dose
Change from baseline in heart rate
Pre-dose and 48 hours post-dose
Change from baseline in blood pressure
Pre-dose and 48 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
PF-06700841: IR followed by MREXPERIMENTALParticipants receive PF-06700841 Immediate release tablets (IR) followed by PF-06700841 Modified release tablets (MR)
PF-06700841: MR followed by IREXPERIMENTALParticipants receive PF-06700841 Modified release tablets (MR) followed by PF-06700841 Immediate release tablets (IR)

Interventions

NameTypeDescription
PF-06700841 Immediate release tabletsDRUGSmall molecule tablets in immediate release form
PF-06700841 Modified release tabletsDRUGSmall molecule tablets in modified release form
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Healthy male, and female participants between the ages of 18 and 55 years at the time of screening, inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse...

Countries:Belgium
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Frequently asked questions about PF-06700841 Immediate release

What is PF-06700841 Immediate release?

PF-06700841 Immediate release is an investigational small molecule developed by Pfizer, Inc. (NYSE: PFE). It is formulated as immediate release tablets. The drug has been studied in a Phase 1 clinical trial in healthy participants. Its therapeutic area is classified as other, and specific indications have not been disclosed.

Who makes PF-06700841 Immediate release?

PF-06700841 Immediate release is being developed by Pfizer, Inc., which trades on the New York Stock Exchange under the ticker symbol PFE. Pfizer is the sponsor of the clinical program for this investigational small molecule.

What phase is PF-06700841 Immediate release in?

PF-06700841 Immediate release is in Phase 1 clinical development. The single trial conducted for this formulation was a Phase 1 study that has been completed. The drug is investigational and has not been approved by the FDA for any indication.

What clinical trials is PF-06700841 Immediate release in?

PF-06700841 Immediate release has been evaluated in one completed Phase 1 trial, NCT03765554, titled "Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulations." The trial enrolled 8 healthy participants in Belgium and was randomized and controlled, though not double-blind.

Is PF-06700841 Immediate release the same as PF-06700841 Immediate release tablets?

Yes, PF-06700841 Immediate release tablets is another name for PF-06700841 Immediate release. Both refer to the same investigational small molecule developed by Pfizer, Inc. (PFE) that has been studied in a Phase 1 clinical trial.