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PF-06700841 Immediate release

Phase 1

Healthy Participants | Small molecule | Other |Pfizer, Inc.|Last Updated: May 9, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment8

FDA Designations

No designations recorded

Clinical trial landscape

PF-06700841 Immediate release · 1 trial · 1 indication

Phase 1 1
NCT03765554Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different FormulationsHealthy Participants
COMPLETED8 Analytics
PHASE1COMPLETED
Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulations
Healthy ParticipantsUnlock trial analytics

Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Area under the plasma concentration-time curve from time zero to the last measured concentration (AUClast) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Time to reach maximum observed plasma concentration (Tmax) of PF-06700841
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose
Area under the plasma concentration-time curve from time zero to extrapolated infinite time (AUCinf) of PF-06700841 if data permit
pre-dose, 1,2,4,6,8,10,12,16,24,28,32,36,48 hour post-dose

Secondary Endpoints

Change from baseline in 12-Lead Electrocardiogram (ECG) parameters - PR interval, QRS complex, QT interval and QTC interval
Pre-dose and 48 hours post-dose
Change from baseline in heart rate
Pre-dose and 48 hours post-dose
Change from baseline in blood pressure
Pre-dose and 48 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
PF-06700841: IR followed by MREXPERIMENTALParticipants receive PF-06700841 Immediate release tablets (IR) followed by PF-06700841 Modified release tablets (MR)
PF-06700841: MR followed by IREXPERIMENTALParticipants receive PF-06700841 Modified release tablets (MR) followed by PF-06700841 Immediate release tablets (IR)

Interventions

NameTypeDescription
PF-06700841 Immediate release tabletsDRUGSmall molecule tablets in immediate release form
PF-06700841 Modified release tabletsDRUGSmall molecule tablets in modified release form
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Healthy male, and female participants between the ages of 18 and 55 years at the time of screening, inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse...

Countries:Belgium
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Frequently asked questions about PF-06700841 Immediate release

What is PF-06700841 Immediate release used for?

PF-06700841 Immediate release is an investigational small molecule being studied in healthy participants. It is currently in Phase 1 clinical development, with a completed trial evaluating blood concentrations after oral dosing. The drug is not approved and remains in clinical development.

Who makes PF-06700841 Immediate release?

PF-06700841 Immediate release is being developed by Pfizer, Inc. (NYSE: PFE). The company is conducting clinical trials to evaluate the drug's pharmacokinetics in healthy participants.

What phase is PF-06700841 Immediate release in?

PF-06700841 Immediate release is in Phase 1 clinical development. One Phase 1 trial has been completed, and the drug remains investigational. It is not approved for any use.

What clinical trials is PF-06700841 Immediate release in?

PF-06700841 Immediate release has one completed clinical trial, NCT03765554, titled 'Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulations.' This Phase 1 study enrolled 8 healthy participants in Belgium.

Is PF-06700841 Immediate release the same as PF-06700841?

PF-06700841 Immediate release is a formulation of the investigational drug PF-06700841. The immediate release version is being studied to evaluate blood concentrations after oral dosing, as part of the drug's clinical development program.