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PF-06273588

Phase 1

Undisclosed | Small molecule | Other |Pfizer, Inc.|Trials Updated: Sep 9, 2011

PF-06273588 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Aug 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment5

FDA Designations

No designations recorded

PF-06273588 clinical trials

PF-06273588 · 1 trial · 1 indication

Phase 1 1
NCT01408355A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.Healthy Volunteers
COMPLETED5 Analytics
PHASE1COMPLETED
A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.
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Study Endpoints

Primary Endpoints

The number of participants with Adverse Events as a measure of Safety and tolerability.
3 days
Pharmacokinetics : peak plasma concentration
3 days
Pharmacokinetics : time of peak plasma concentration
3 days
Pharmacokinetics : area under plasma concentration-time curve
3 days
Pharmacokinetics : Terminal plasma half life
3 days
Pharmacokinetics : Plasma Clearance
3 days
Pharmacokinetics : plasma volume of distribution
3 days
Pharmacokinetics : oral bioavailability
3 days
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
50 microgram PF-06273588 intravenousEXPERIMENTALSubjects will receive a single intravenous microdose of PF-06273588 in period one
50 microgram PF-06273588 oralEXPERIMENTALSubjects will receive a single oral microdose of PF-06273588 in period two

Interventions

NameTypeDescription
PF-06273588DRUGIntravenous, 50 microgram, single dose
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Eligibility Criteria

Age Range18 Years to 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male subjects between the ages of 18 and 55 years (inclusive). Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurements, 12-lead ECG and clinical...

Countries:United Kingdom
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Frequently asked questions about PF-06273588

What is PF-06273588?

PF-06273588 is an investigational small molecule developed by Pfizer, Inc. (ticker: PFE). It has been studied in a Phase 1 clinical trial in healthy male volunteers in the United Kingdom. The specific therapeutic indication for PF-06273588 has not been disclosed.

Who is developing PF-06273588?

PF-06273588 is being developed by Pfizer, Inc., which trades on the New York Stock Exchange under the ticker PFE. Pfizer sponsored the Phase 1 clinical trial of PF-06273588 conducted in the United Kingdom.

What phase is PF-06273588 in?

PF-06273588 is in Phase 1 clinical development. It is an investigational small molecule and has not been approved by the FDA. The single Phase 1 trial of PF-06273588 has been completed.

What clinical trials is PF-06273588 in?

PF-06273588 has been evaluated in one clinical trial: NCT01408355, titled "A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose." This Phase 1 trial enrolled 5 healthy male volunteers in the United Kingdom and is completed.

What was studied in the PF-06273588 Phase 1 trial?

The Phase 1 trial NCT01408355 investigated the elimination of PF-06273588 from the body following a single low dose. The study was controlled, enrolled 5 healthy male volunteers aged 18 years and older, and was conducted in the United Kingdom. The trial is completed.