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PF-06273588

Phase 1

Healthy Volunteers | Small molecule | Other |Pfizer, Inc.|Last Updated: Sep 9, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment5

FDA Designations

No designations recorded

Clinical trial landscape

PF-06273588 · 1 trial · 1 indication

Phase 1 1
NCT01408355A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.Healthy Volunteers
COMPLETED5 Analytics
PHASE1COMPLETED
A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.
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Study Endpoints

Primary Endpoints

The number of participants with Adverse Events as a measure of Safety and tolerability.
3 days
Pharmacokinetics : peak plasma concentration
3 days
Pharmacokinetics : time of peak plasma concentration
3 days
Pharmacokinetics : area under plasma concentration-time curve
3 days
Pharmacokinetics : Terminal plasma half life
3 days
Pharmacokinetics : Plasma Clearance
3 days
Pharmacokinetics : plasma volume of distribution
3 days
Pharmacokinetics : oral bioavailability
3 days
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
50 microgram PF-06273588 intravenousEXPERIMENTALSubjects will receive a single intravenous microdose of PF-06273588 in period one
50 microgram PF-06273588 oralEXPERIMENTALSubjects will receive a single oral microdose of PF-06273588 in period two

Interventions

NameTypeDescription
PF-06273588DRUGIntravenous, 50 microgram, single dose
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Eligibility Criteria

Age Range18 Years to 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male subjects between the ages of 18 and 55 years (inclusive). Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurements, 12-lead ECG and clinical...

Countries:United Kingdom
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Frequently asked questions about PF-06273588

What is PF-06273588 used for?

PF-06273588 is an investigational small molecule being studied in healthy volunteers. It is being evaluated to understand how the drug is eliminated from the body after a single low dose. The drug is in Phase 1 clinical development and is not yet approved for any medical use.

Who makes PF-06273588?

PF-06273588 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The company is conducting clinical trials to investigate the properties of this investigational small molecule drug.

What phase is PF-06273588 in?

PF-06273588 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug is being studied in healthy volunteers to assess its elimination from the body following a single low dose.

What clinical trials is PF-06273588 in?

PF-06273588 has one completed clinical trial registered as NCT01408355. This Phase 1 study investigated the elimination of PF-06273588 from the body following a single low dose. The trial enrolled 5 healthy male volunteers in the United Kingdom and has been completed.

Is PF-06273588 the same as any other drug?

PF-06273588 is the primary identifier for this investigational drug. No alternative names have been reported for this compound in clinical trial registrations. It is a small molecule being developed by Pfizer for research purposes in healthy volunteers.