Recent Updates
Recently added Catalysts

PF-05212372

Phase 1

Phase 1 | Small molecule | Other |Pfizer, Inc.|Last Updated: Aug 15, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01415102A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Inhaled Doses Of PF-05212372.PHASE1 COMPLETED 24Sep 1, 2010Dec 1, 2010Aug 15, 20111 Belgium
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
14 days
Plasma pharmacokinetics
up to 72 hours post dose
Urine pharmacokinetics
up to 24 hours post dose
Urine Pharmacodynamics
up to 24 hours post dose
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Cohort 1EXPERIMENTALSubjects will be assigned to receive either PF-05212372 or placebo in each period
Cohort 2EXPERIMENTALSubjects will be assigned to receive either PF-05212372 or placebo in each period
Interventions
NameTypeDescription
PF-05212372DRUGInhaled. Dose Level 1: 50 ug
PlaceboDRUGInhaled
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: Healthy subjects. (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ECG and clinical laboratory tests). Exclusion Criteria: * Evidence or...

Countries:Belgium
Unlock Eligibility Criteria