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HKI-357

Phase 1

Healthy | Small molecule | Other |Pfizer, Inc.|Last Updated: Jul 10, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment72
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00550381Study Evaluating the Safety, Tolerability, and Pharmacokinetics (PK) of HKI-357 Administered Orally to Healthy SubjectsPHASE1 COMPLETED 72Jan 1, 2008Mar 1, 2008Jul 10, 2009 -
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Study Endpoints
Primary Endpoints
Safety, tolerability, PK
5 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1PLACEBO_COMPARATOR10mg
2PLACEBO_COMPARATOR20mg
3PLACEBO_COMPARATOR40mg
4PLACEBO_COMPARATOR80mg
5PLACEBO_COMPARATOR160mg
6PLACEBO_COMPARATOR240mg
7PLACEBO_COMPARATOR400mg
8PLACEBO_COMPARATOR640mg
9PLACEBO_COMPARATOR960mg
10PLACEBO_COMPARATORplacebo
Interventions
NameTypeDescription
HKI-357DRUGSingle-dose capsule
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Eligibility Criteria
Age Range18 Years — 50 Years
SexALL
Healthy VolunteersYes

Eligibility Criteria: * Healthy adult men or women of nonchildbearing potential, aged 18-50.

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