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Epanutin Infatabs

Phase 1

Healthy | Small molecule | Other |Pfizer, Inc.|Last Updated: Jan 28, 2021

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment26

FDA Designations

No designations recorded

Clinical trial landscape

Epanutin Infatabs · 1 trial · 1 indication

Phase 1 1
NCT01355068A Study to Assess if Epanutin Infatabs 50 mg From Germany Are Similar to Dilantin Infatabs 50 mg From AustraliaHealthy
COMPLETED26 Analytics
PHASE1COMPLETED
A Study to Assess if Epanutin Infatabs 50 mg From Germany Are Similar to Dilantin Infatabs 50 mg From Australia
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
0 (pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48, and 72 hours (hrs) post-dose

Area under the plasma concentration time-curve from zero (pre-dose) to the last measured concentration (AUClast).

Maximum Observed Plasma Concentration (Cmax)
0 (pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hrs post-dose

Secondary Endpoints

Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUC [0-∞])
0 (pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hrs post-dose
Extrapolated Area Under the Curve (AUC Percent [%] Extrap)
0 (pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hrs post-dose
Plasma Decay Half Life (t1/2)
0 (pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hrs post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Treatment AACTIVE_COMPARATOREpanutin Infatabs 50 mg (sourced from Germany), 1 x 50 mg (REFERENCE)
Treatment BEXPERIMENTALDilantin Infatabs 50 mg (sourced from Australia), 1 x 50 mg (TEST)

Interventions

NameTypeDescription
Epanutin Infatabs (Phenytoin)DRUGChewable Tablet, 50 mg, Single dose
Dilantin Infatabs (Phenytoin)DRUGChewable Tablet, 50 mg, Single dose
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Eligibility Criteria

Age Range21 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and/or female subjects between the ages of 21 and 55 years, inclusive. * An informed consent document signed and dated by the subject. Exclusion Criteria: * Evidence or history of clinically significant abnormalities. * Any condition possibly affecting drug abso...

Countries:Singapore
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Frequently asked questions about Epanutin Infatabs

What is Epanutin Infatabs used for?

Epanutin Infatabs is a small molecule drug being studied in healthy volunteers. It is currently in Phase 1 clinical development, with one completed trial assessing its similarity to another formulation. The drug is being developed by Pfizer, Inc. and is not yet approved for any indication.

Who makes Epanutin Infatabs?

Epanutin Infatabs is developed by Pfizer, Inc., which trades under the ticker symbol PFE. The company is conducting clinical research on this small molecule drug, which is currently in Phase 1 development for use in healthy volunteers.

What phase is Epanutin Infatabs in?

Epanutin Infatabs is in Phase 1 clinical development. One Phase 1 trial has been completed, and there are no active trials currently ongoing. The drug remains investigational and has not received FDA approval.

What clinical trials is Epanutin Infatabs in?

Epanutin Infatabs has one completed clinical trial, NCT01355068, titled 'A Study to Assess if Epanutin Infatabs 50 mg From Germany Are Similar to Dilantin Infatabs 50 mg From Australia.' This Phase 1 study enrolled 26 healthy volunteers in Singapore and was active-controlled.

Is Epanutin Infatabs the same as Dilantin Infatabs?

Epanutin Infatabs and Dilantin Infatabs are being compared in a clinical trial to assess if they are similar. The study NCT01355068 evaluated whether Epanutin Infatabs 50 mg from Germany is similar to Dilantin Infatabs 50 mg from Australia, but the results have not been reported.