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Eletriptan commercial

Phase 1

Undisclosed | Small molecule | Other |Pfizer, Inc.|Trials Updated: Jan 28, 2021

Eletriptan commercial target and mechanism

Molecular targetHTR1B, HTR1D, HTR1F
Target classAgonist
ModalitySmall molecule

Also known as Eletriptan commercial tablet

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment16

FDA Designations

No designations recorded

Eletriptan commercial clinical trials

Eletriptan commercial · 1 trial · 1 indication

Phase 1 1
NCT01139515Eletriptan Pharmacokinetics In Korean MalesHealthy
COMPLETED16 Analytics
PHASE1COMPLETED
Eletriptan Pharmacokinetics In Korean Males
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0-∞)]
Pre-dosing, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, and 24 hrs post dose (A,B,C) and additional 2.5,2.75,3.5,5,14,18 and 26 hrs post dose(D)

AUC (0-∞) = Area under the plasma concentration versus time curve (AUC) from time zero (pre-dose) to extrapolated infinite time (0-∞). It is obtained from AUC (0-t) plus AUC (t-∞).

AUC From Time Zero to Last Quantifiable Concentration (AUClast)
Pre-dosing, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, and 24 hrs post dose (A,B,C) and additional 2.5,2.75,3.5,5,14,18 and 26 hrs post dose (D)

Area under the plasma concentration-time curve from time zero (pre-dose) to the time of the last measurable concentration (AUClast).

Maximum Observed Plasma Concentration (Cmax)
Pre-dosing, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, and 24 hrs post dose (A,B,C) and additional 2.5,2.75,3.5,5,14,18 and 26 hrs post dose (D)

Secondary Endpoints

Time to Reach Maximum Observed Plasma Concentration (Tmax)
Pre-dosing, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, and 24 hrs post dose (A,B,C) and additional 2.5,2.75,3.5,5,14,18 and 26 hrs post dose (D)
Plasma Decay Half Life (t1/2)
Pre-dosing, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, and 24 hrs post dose (A,B,C) and additional 2.5,2.75,3.5,5,14,18 and 26 hrs post dose (D)
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Treatment AEXPERIMENTAL1 X 20 mg eletriptan
Treatment BEXPERIMENTAL1 X 40 mg eletriptan
Treatment CEXPERIMENTAL2 X 40 mg eletriptan
Treatment DEXPERIMENTAL1 X 40 mg tablet given 2 hr after initial 1 X 40 mg tablet dose

Interventions

NameTypeDescription
Eletriptan commercial tabletDRUG20 mg tablet, single dose
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Eligibility Criteria

Age Range18 Years to 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * healthy male subjects, 18-55 years old * Body Mass Index (BMI) of 17.5 to 30.5 kg/m2 * provide informed consent Exclusion Criteria: * blood pressure \>140/90 mm Hg * any condition possibly affecting drug absorption * positive urine drug screen

Countries:South Korea
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Frequently asked questions about Eletriptan commercial

What is Eletriptan commercial?

Eletriptan commercial is a small molecule drug candidate developed by Pfizer, Inc. under the ticker PFE. It is also known as the Eletriptan commercial tablet. The program is in Phase 1 clinical development, and the specific medical condition it is being studied for has not been disclosed.

What does Eletriptan commercial target?

Eletriptan commercial targets the serotonin receptors HTR1B, HTR1D, and HTR1F, where it acts as an agonist. By activating these receptor subtypes, the drug is designed to influence serotonin signaling pathways. This target profile places it in the agonist class of small molecule therapeutics.

Who makes Eletriptan commercial?

Eletriptan commercial is being developed by Pfizer, Inc., which trades under the ticker symbol PFE. Pfizer is the sponsor responsible for advancing this small molecule program through clinical testing. The asset is also referred to as the Eletriptan commercial tablet.

What phase is Eletriptan commercial in?

Eletriptan commercial is in Phase 1 clinical development. It has not been approved by the FDA and remains an investigational agent. One Phase 1 trial has been completed, and there are currently no active trials listed for this program.

What clinical trials is Eletriptan commercial in?

Eletriptan commercial has been evaluated in one completed Phase 1 trial, NCT01139515, titled Eletriptan Pharmacokinetics In Korean Males. The study enrolled 16 healthy male volunteers aged 18 years and older in South Korea. It was a randomized, controlled trial with a pharmacokinetic focus.

Is Eletriptan commercial the same as Eletriptan commercial tablet?

Yes, Eletriptan commercial tablet is an alternative name for Eletriptan commercial. Both names refer to the same Pfizer-developed small molecule candidate. The tablet designation reflects the oral dosage form of this Phase 1 asset.