Recent Updates
Recently added Catalysts

DVS-233

Phase 3

Depression | Small molecule | Psychiatry |Pfizer, Inc.|Last Updated: Aug 19, 2009

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment244

FDA Designations

No designations recorded

Clinical trial landscape

DVS-233 · 11 trials · 7 indications

Phase 3 11
NCT00195546Study Evaluating DVS-233 SR for Treatment of Vasomotor Symptoms Associated With MenopauseMenopause
COMPLETED465 Analytics
NCT00256685Study Evaluating DVS-233 SR to Treat Vasomotor Systems Associated With MenopauseMenopause
COMPLETED568 Analytics
NCT00452595Study Evaluating DVS-233 for Treatment of Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED- Analytics
NCT00421031Study Evaluating the Safety & Efficacy of DVS-223 SR for Relief of Vasomotor Symptoms Associated With MenopauseVasomotor Symptoms
COMPLETED540 Analytics
NCT00063206Study Evaluating DVS-233 in Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED247 Analytics
NCT00072774Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED480 Analytics
NCT00073762Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED375 Analytics
NCT00075257Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED603 Analytics
NCT00087737Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED369 Analytics
NCT00090649Study Evaluating DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive DisorderMajor Depressive Disorder
COMPLETED369 Analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR for Treatment of Vasomotor Symptoms Associated With Menopause
MenopauseUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR to Treat Vasomotor Systems Associated With Menopause
MenopauseUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 for Treatment of Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating the Safety & Efficacy of DVS-223 SR for Relief of Vasomotor Symptoms Associated With Menopause
Vasomotor SymptomsUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 in Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics
PHASE3COMPLETED
Study Evaluating DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive Disorder
Major Depressive DisorderUnlock trial analytics

Study Endpoints

Primary Endpoints

To assess the efficacy and safety of DVS-233 SR compared with placebo for treatment of vasomotor symptoms (VMS) associated with menopause and to compare the bleeding incidence of DVS-233 SR and tibolone.
Reduction in average daily number of moderate & severe hot flushes and average daily severity score at weeks 4 & 12
HAM-D17
The primary objective is to assess the efficacy and safety of 4 doses of DVS-233 SR as compared to placebo for the treatment of moderate to severe VMS associated with menopause.

Secondary Endpoints

To assess the effects of DVS-233 SR and tibolone on changes from baseline in weight, breast pain, and health outcomes indicators.
Sleep, mood
MADRS, CGI-S, CGI-I, Covi Anxiety Scale, SDS, VAS-PI, and WHO-5
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
DVS-233DRUG -
DVS-233 SRDRUG -
DVS-233 SR (desvenlafaxine sustained release )DRUG -
Venlafaxine ERDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range40 Years to 65 Years
SexFEMALE
Healthy VolunteersNo
Study Sites41

Inclusion Criteria: * Postmenopausal women of age 40 to 65 seeking treatment for hot flashes with last natural menstrual period (LNMP) completed at least 12 months prior to screening. * Minimum of 7 moderate to severe hot flashes per day or 50 per week recorded for 7 consecutive days * Body Mass In...

Countries:BelgiumCroatiaCzechiaFinlandFranceHungaryMexicoNetherlandsPolandRomaniaSouth AfricaSpainSwedenUkraineUnited KingdomUnited States
Unlock Eligibility Criteria

Frequently asked questions about DVS-233

What is DVS-233 used for?

DVS-233 is an investigational small molecule being studied for the treatment of vasomotor symptoms associated with menopause, as well as for major depressive disorder. It is being developed by Pfizer, Inc. (NYSE: PFE) and has completed Phase 3 clinical trials in these indications.

What does DVS-233 target?

DVS-233 is a small molecule being developed for psychiatric and menopausal conditions. Its specific molecular target has not been disclosed in the available clinical trial information. The drug is being studied for its effects on vasomotor symptoms and major depressive disorder.

Who makes DVS-233?

DVS-233 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. Pfizer has conducted multiple Phase 3 clinical trials of DVS-233 for menopause-related vasomotor symptoms and major depressive disorder.

What phase is DVS-233 in?

DVS-233 has completed Phase 3 clinical trials. All seven recorded trials for DVS-233 are completed, with no active trials currently ongoing. The drug remains investigational and has not been reported as approved by regulatory authorities.

What clinical trials has DVS-233 been in?

DVS-233 has been studied in seven completed clinical trials, including NCT00092911 in major depressive disorder, NCT00195546 and NCT00256685 in vasomotor symptoms associated with menopause, and NCT00421031 for relief of vasomotor symptoms. These trials enrolled a total of 2,443 participants.

Is DVS-233 the same as desvenlafaxine?

DVS-233 is an investigational compound being developed by Pfizer. The clinical trial records for DVS-233 do not list alternative names, so it is not identified as desvenlafaxine in the available data. The drug is being studied for vasomotor symptoms and major depressive disorder.