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CE-326,597

Phase 2

Weight Management | Small molecule | Metabolic |Pfizer, Inc.|Last Updated: Nov 7, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment252
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00542009A Trial In Diabetic Patients To Assess Effect Of CE-326,597 On Glucose Control And Body WeightPHASE2 COMPLETED 252Dec 1, 2007Nov 1, 2008Nov 7, 201254 United States, Bulgaria +5
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Study Endpoints
Primary Endpoints
Glucose control
At Day 84
Body weight
At Day 84
Secondary Endpoints
Regimen (dose or number) of anti-diabetic agents
At Day 84
GlycoMark
On Day 84
Waist circumference
On Day 84
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
CE-326,597 100 mg QDEXPERIMENTAL -
CE-326,597 50 mg QDEXPERIMENTAL -
CE-326,597 25 mg QDEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
CE-326,597 5mg QDEXPERIMENTAL -
Interventions
NameTypeDescription
CE-326,597 100 mg QDDRUGAdministered orally, once daily with morning meal for duration of trial (84 days).
CE-326,597 50 mg QDDRUGAdministered orally, once daily with morning meal for duration of trial (84 days).
CE-326,597 25 mg QDDRUGAdministered orally, once daily with morning meal for duration of trial (84 days).
PlaceboDRUGPlacebo to match CE-326,597 tablets to be administered orally, once daily with morning meal for duration of trial (84 days).
CE-326,597 5mg QDDRUGAdministered orally, once daily with morning meal for duration of trial (84 days).
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites54

Inclusion Criteria: Patients with type 2 diabetes, not on any or on oral (up to 2) anti-diabetic medications, otherwise medically stable. Exclusion Criteria: Women of childbearing potential, people with unstable medical conditions, people with gallstones

Countries:United StatesBulgariaCanadaIndiaMexicoPuerto RicoSpain
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