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Artesunate

Phase 1

Falciparum Malaria | Small molecule | Infectious Disease |Pfizer, Inc.|Last Updated: Jun 25, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
ACTIVE_CONTROLLED
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00894374Bioequivalence Study Comparing Artesunate Tablet To Arsuamoon® Tablets (Guilin-China) In Healthy SubjectsPHASE1 COMPLETED 40Jun 1, 2009Aug 1, 2009Jun 25, 20101 Singapore
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Study Endpoints
Primary Endpoints
AUC and Cmax of active metabolite of artesunate
30-Aug-2009
Secondary Endpoints
Tolerability
30-Aug-2009
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Artesunate (Pfizer)EXPERIMENTAL -
Artesunate (Arsuamoon® Tablets Guilin-China)ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Artesunate (Test)DRUGOral tablet, single dose, 1 x 100 mg
Artesunate (Comparator)DRUGOral tablet, single dose, 2 x 50 mg
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Eligibility Criteria
Age Range21 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and/or female subjects between the ages of 21 and 55 years, inclusive. * BMI of 18 to 30 kg/m2; and a total body weight \>45 kg (99 lbs). * An informed consent document signed and dated by the subject or a legally acceptable representative. Exclusion Criteria: *...

Countries:Singapore
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