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AN3365

Phase 1

Gram-negative Bacterial Infection | Small molecule | Infectious Disease |Pfizer, Inc.|Last Updated: Mar 5, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01015014Safety, Pharmacokinetics (PK) and Tolerability Study of a Novel Drug for Treatment of Bacterial InfectionsPHASE1 COMPLETED 64Nov 5, 2009May 13, 2010Mar 5, 20191 Australia
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Study Endpoints
Primary Endpoints
Clinical safety data from 12-lead ECG, clinical laboratory tests, urinalysis, injection site tolerability, spontaneous/elicited adverse event reporting, and vital signs (blood pressure, heart rate, respiratory rate)
Multiple time points up to 14 days
Secondary Endpoints
Assessment of pharmacokinetic parameters to achieve appropriate exposure and estimate the dose proportionality
Multiple time points up to 14 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
AN3365ACTIVE_COMPARATOR -
SalinePLACEBO_COMPARATOR -
Interventions
NameTypeDescription
AN3365DRUGLP, 600 mg vial; reconstituted in Normal Saline
PlaceboDRUG0.9% sodium chloride for injection
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Eligibility Criteria
Age Range18 Years — 45 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Young healthy males, 18-45 years (inclusive) of age * Healthy as judged by a responsible physician with no clinically significant abnormality * Surgically sterile OR agrees to abstain from sexual intercourse with a female partner OR agrees to use a condom and spermicide during...

Countries:Australia
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