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ORMD 0801

Phase 2

Brittle Type I Diabetes Mellitus | Small molecule | Metabolic |Oramed Pharmaceuticals Inc.|Last Updated: Aug 11, 2011

Target and mechanism

ModalitySmall molecule

Also known as ORMD-0801

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

ORMD 0801 · 1 trial · 1 indication

Phase 2 1
NCT00867594Effectiveness of Oral Insulin in Unstable Type 1 Diabetes PatientsBrittle Type I Diabetes Mellitus
COMPLETED12 Analytics
PHASE2COMPLETED
Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients
Brittle Type I Diabetes MellitusUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine the safety and tolerability of multi-doses of Oramed oral insulin in people with type 1 diabetes
15 days

Secondary Endpoints

To determine if oral insulin is likely to improve glycemic stability assessed by the reduction of the frequency and severity of hypoglycemic episodes in people with unstable type 1 diabetes
15 days
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
ORMD 0801DRUG1 capsule ORMD 0801 3 times a day, before each meal
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Eligibility Criteria

Age Range18 Years to 50 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Type 1 diabetes mellitus * Male or female aged 18-50 years inclusive * Body weight between 50-100kg and BMI between 18 and 30 kg/m2 * Diagnosed 6 or more months ago, unstable diabetes with frequent episodes of hypoglycemia * No other medical problems Exclusion Criteria: * Hi...

Countries:Israel
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Frequently asked questions about ORMD 0801

What is ORMD-0801 used for?

ORMD-0801 is an investigational oral insulin capsule being developed for metabolic conditions, including Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus, and Nonalcoholic Steatohepatitis (NASH). It is currently in Phase 2 clinical development and is not yet approved by regulatory authorities.

Who makes ORMD-0801?

ORMD-0801 is being developed by Oramed Pharmaceuticals Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol ORMP. The company is focused on oral delivery of proteins and peptides for metabolic diseases.

What phase is ORMD-0801 in?

ORMD-0801 is in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or other regulatory agencies. Multiple Phase 2 trials have been completed, and the drug remains under clinical investigation for diabetes and NASH indications.

What clinical trials is ORMD-0801 in?

ORMD-0801 has been studied in several Phase 2 trials, including NCT02094534 in Type 1 Diabetes, NCT02496000 in Type 2 Diabetes, NCT02954601 in Type 2 Diabetes Mellitus, and NCT04616014 in NASH. These trials were conducted in the United States and Belgium, with a total enrollment of 251 participants across the four studies.

Is ORMD-0801 the same as ORMD-0801 8 mg?

Yes, ORMD-0801 is also known as ORMD-0801 8 mg. The 8 mg designation refers to a specific dose strength of the oral insulin capsule being evaluated in clinical trials. Both names refer to the same investigational drug product developed by Oramed Pharmaceuticals.

How does ORMD-0801 work?

ORMD-0801 is an oral insulin formulation designed to deliver insulin through the gastrointestinal tract. It is being studied to assess its impact on glucose control in diabetic patients and to reduce liver fat content in patients with NASH. The drug aims to provide an oral alternative to injectable insulin.