Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT03561298 | A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects | PHASE1 | COMPLETED | 18 | — | — | Jun 7, 2018 | Jul 2, 2018 | Nov 4, 2019 | 1 | United States |
AUC from time 0 to the last quantifiable concentration (AUC0-t)
| Arm | Type | Description |
|---|---|---|
| Single Arm: BGB-3111 + Drug Cocktail | EXPERIMENTAL | BGB-3111 and Drug Cocktail (midazolam, warfarin, omeprazole, digoxin and rosuvastatin) |
| Name | Type | Description |
|---|---|---|
| BGB-3111 and Drug Cocktail | DRUG | BGB-3111 and Drug Cocktail (midazolam, warfarin, omeprazole, digoxin and rosuvastatin) |
Inclusion Criteria: All Groups * Male subjects in good health as determined by past medical history, physical examination, vital signs, ECG and laboratory tests at screening. * Subjects must have a body mass index (BMI) between 18 and 32 kg/m2. * Male subjects must agree to a highly effective metho...