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OMS201

Phase 1

Urinary Calculi | Small molecule | Nephrology |Omeros Corporation|Last Updated: Oct 12, 2012

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment29

FDA Designations

No designations recorded

Clinical trial landscape

OMS201 · 2 trials · 5 indications

Phase 1 2
NCT00857090Pharmacokinetic, Safety and Efficacy Study of OMS201 in Subjects Undergoing Retrograde Ureteroscopic Removal of Upper Urinary Tract StonesUrinary Calculi
COMPLETED18 Analytics
NCT00599664Pharmacokinetic and Safety Study of OMS201 in Subjects Undergoing Ureteroscopic Treatment for Removal of Urinary Tract-Located StonesUrinary Calculi
COMPLETED11 Analytics
PHASE1COMPLETED
Pharmacokinetic, Safety and Efficacy Study of OMS201 in Subjects Undergoing Retrograde Ureteroscopic Removal of Upper Urinary Tract Stones
Urinary CalculiUnlock trial analytics
PHASE1COMPLETED
Pharmacokinetic and Safety Study of OMS201 in Subjects Undergoing Ureteroscopic Treatment for Removal of Urinary Tract-Located Stones
Urinary CalculiUnlock trial analytics

Study Endpoints

Primary Endpoints

Peak systemic exposure.
Day of surgery
Pharmacokinetic
Day of Surgery

Secondary Endpoints

Safety
Day 7
Degree of pain
7 days
Duration of the operation
Day of surgery
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTALDrug
2PLACEBO_COMPARATORVehicle

Interventions

NameTypeDescription
OMS201DRUGStage 1: OMS201 irrigation solution at 3X the base concentration during surgery Stage 2: OMS201 irrigation solution up to 10X the base concentration during surgery
VehicleDRUGStages 1-2: Vehicle irrigation solution during surgery
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites4

Inclusion Criteria: * 18 - 65 years of age. * Subject is undergoing retrograde ureteroscopic removal of renal-collecting system or ureteral stones for which general anesthesia will be used. Exclusion Criteria: * No allergies to any of the individual ingredients in OMS201. * Subject taking a prohi...

Countries:United States
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Frequently asked questions about OMS201

What is OMS201 used for?

OMS201 is an investigational small molecule being developed for use in urinary calculi, which are urinary tract stones. It is intended for patients undergoing ureteroscopic procedures to remove stones located in the urinary tract, including the upper urinary tract and kidneys.

Who makes OMS201?

OMS201 is being developed by Omeros Corporation, a biopharmaceutical company traded on the Nasdaq under the ticker symbol OMER. The company is conducting clinical research on this investigational drug for the treatment of urinary stones.

What phase is OMS201 in?

OMS201 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. Two Phase 1 trials have been completed, and the drug is no longer in active clinical testing according to the available trial data.

What clinical trials is OMS201 in?

OMS201 has been studied in two completed Phase 1 clinical trials. The first, NCT00599664, enrolled 11 subjects undergoing ureteroscopic treatment for urinary tract stones. The second, NCT00857090, enrolled 18 subjects undergoing retrograde ureteroscopic removal of upper urinary tract stones. Both trials were conducted in the United States.

Is OMS201 the same as any other drug?

OMS201 is a unique investigational drug candidate developed by Omeros Corporation. No alternative names for OMS201 have been reported in the clinical trial data, and it is not known to be the same as any other marketed or investigational medication.