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OMS103HP

Phase 3

Knee Injuries | Small molecule | Other |Omeros Corporation|Last Updated: Oct 12, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment647
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00226772Efficacy and Safety of OMS103HP in Patients Undergoing Autograft Anterior Cruciate Ligament (ACL) ReconstructionPHASE3 COMPLETED 326Jun 1, 2005Mar 1, 2011Oct 12, 201218 United States, Canada
NCT00226759Efficacy and Safety of OMS103HP in Patients Undergoing Allograft Anterior Cruciate Ligament (ACL) ReconstructionPHASE3 COMPLETED 321Nov 1, 2004Mar 1, 2011Oct 12, 201220 United States, Canada
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Study Endpoints
Primary Endpoints
Improvement in knee function
30 days
Secondary Endpoints
Decreased pain
30 days
Improved range of motion
30 days
Earlier return to work
30 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
OMS103HP irrigation solutionEXPERIMENTALDrug
vehicle irrigation solutionPLACEBO_COMPARATORVehicle
Interventions
NameTypeDescription
OMS103HPDRUGMaximum of 39 liters of OMS103HP irrigation solution over a maximum of 2 hours
VehicleDRUGMaximum of 39 liters of vehicle irrigation solution over a maximum of 2 hours
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Eligibility Criteria
Age Range15 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites18

Inclusion Criteria: * 15 - 65 years of age * In good general health with an ACL tear that occurred from 2 weeks to 18 months prior to the day of arthroscopic surgery * Undergoing primary unilateral ACL reconstruction using a medial hamstring (semitendinosus and gracilis) autograft * Able to partici...

Countries:United StatesCanada
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Competitive Landscape -Knee Injuries 5 trials
CompanyTickerTrialsLead PhaseDrugs
Zimmer Biomet Holdings, Inc.ZBH1NAUndisclosed
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