Recent Updates
Recently added Catalysts

etonogestrel with testosterone undecanoate

Phase 2

Contraception | Small molecule | Endocrine |Organon & Co.|Last Updated: Feb 4, 2022

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment350

FDA Designations

No designations recorded

Clinical trial landscape

etonogestrel with testosterone undecanoate · 1 trial · 1 indication

Phase 2 1
NCT00403793Hormonal Contraception in Healthy Young Men (P42306)(COMPLETED)(P06057)Contraception
COMPLETED350 Analytics
PHASE2COMPLETED
Hormonal Contraception in Healthy Young Men (P42306)(COMPLETED)(P06057)
ContraceptionUnlock trial analytics

Study Endpoints

Primary Endpoints

% of men who had a sperm concentration of 1 million/ml or less at week 16.
Week 16

Secondary Endpoints

Semen Parameters
At several timepoints during treatment
Reversibility of Suppression
Post-Treatment
Hormones
At several timepoints
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Arm 1ACTIVE_COMPARATORetonogestrel with testosterone undecanoate
Arm 2PLACEBO_COMPARATORPlacebo

Interventions

NameTypeDescription
etonogestrel with testosterone undecanoateDRUG42 or 44 weeks with etonogestrel implant and testosterone undecanoate injections every 10 to 12 weeks
PlaceboDRUG42 or 44 weeks with placebo implant and placebo injections
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 45 Years
SexMALE
Healthy VolunteersYes

Inclusion Criteria: * Male * Mentally and physically healthy * BMI between 18 and 32 kg/m\^2 * Two pre-treatment semen samples \> 20 million/ml with normal morphology and motility Exclusion Criteria: * History or presence of psychiatric disease, liver disease, renal disease, diabetes, cardiovascu...

Unlock Eligibility Criteria

Frequently asked questions about etonogestrel with testosterone undecanoate

What is etonogestrel with testosterone undecanoate used for?

Etonogestrel with testosterone undecanoate is an investigational combination being studied for contraception in healthy young men. It is a small molecule product in Phase 2 clinical development. The combination is intended to provide hormonal contraception for males, though it is not yet approved and remains under investigation.

Who makes etonogestrel with testosterone undecanoate?

Organon & Co. (NYSE: OGN) is developing etonogestrel with testosterone undecanoate. The company is conducting clinical trials to evaluate this combination as a male contraceptive. The product is currently in Phase 2 development and is not yet approved for commercial use.

What phase is etonogestrel with testosterone undecanoate in?

Etonogestrel with testosterone undecanoate is in Phase 2 clinical development. It is an investigational product being studied for contraception in men. The Phase 2 trial has been completed, and the product has not received regulatory approval. Further development stages have not been publicly disclosed.

What clinical trials is etonogestrel with testosterone undecanoate in?

Etonogestrel with testosterone undecanoate has one completed Phase 2 clinical trial, NCT00403793, titled 'Hormonal Contraception in Healthy Young Men (P42306)(COMPLETED)(P06057)'. This randomized, double-blind, placebo-controlled trial enrolled 350 healthy male participants aged 18 years and older to evaluate the combination for contraception.

Is etonogestrel with testosterone undecanoate FDA approved?

Etonogestrel with testosterone undecanoate is not FDA approved. It is an investigational combination currently in Phase 2 clinical development for male contraception. The completed Phase 2 trial, NCT00403793, evaluated its safety and efficacy, but the product has not received marketing authorization from the FDA or other regulatory agencies.