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Asenapine WHITE raspberry flavor

Phase 2

Psychosis | Small molecule | Psychiatry |Organon & Co.|Last Updated: Aug 15, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment174
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00878462An Acceptability Study of Unflavored Asenapine Versus Raspberry Flavored Asenapine in Stable Patients With a Psychotic Disorder (P07010)(COMPLETED)PHASE2 COMPLETED 174Jun 29, 2005Oct 15, 2005Aug 15, 2024 -
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Study Endpoints
Primary Endpoints
The response to the question: "How likely would you be to take this medication for at least 1 year if your doctor continued to prescribe it to you and it worked well?""
After each dose (morning and evening of days 1 through 3)
The response on the following question: "Considering your total impression of this tablet, like the look, the taste and the feel of the tablet, how acceptable is this tablet to you?"
After each dose (morning and evening of days 1 through 3)
Secondary Endpoints
Responses on the following question: "How acceptable was the taste of the tablet?"
After each dose (morning and evening of days 1 through 3)
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
Sequence 1EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment A, C, B, A, C, B. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Sequence 2EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment A, B, C, A, B, C. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Sequence 3EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment B, C, A, B, C, A. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Sequence 4EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment B, A, C, B, A, C. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Sequence 5EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment C, B, A, C, B, A. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Sequence 6EXPERIMENTALSubjects randomly assigned to this sequence receive in order: Treatment C, A, B, C, A, B. Each treatment was one dose, and each patient received a dose in the morning and evening for 3 consecutive days.
Interventions
NameTypeDescription
Asenapine WHITE raspberry flavor (Treatment A)DRUGAsenapine (Org 5222), 5 mg white raspberry flavored as fast dissolving tablets
Asenapine RED raspberry flavor (Treatment B)DRUGAsenapine (Org 5222), 5 mg red raspberry flavored as fast dissolving tablets
Asenapine WHITE UNFLAVORED (Treatment C)DRUGAsenapine (Org 5222), 5 mg WHITE UNflavored as fast dissolving tablets
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * are at least 18 years of age and of legal minimum age for trial participation; * are a male, or a female who is not of childbearing potential * are free from an acute exacerbation of psychosis for at least 3 months; * have a current DSM-IV diagnosis of schizophrenia (paranoid,...

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