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Punctum Plug

Phase 3

Post Ocular Surgical Inflammation and Pain | Small molecule | Pain |Ocular Therapeutix, Inc.|Last Updated: Jan 31, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment247
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02034019Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract SurgeryPHASE3 COMPLETED 247Feb 1, 2014Feb 1, 2015Jan 31, 20201 United States
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Study Endpoints
Primary Endpoints
Absence of Cells in Anterior Chamber of the Study Eye
Day 14
Absence of Pain in Study Eye
Day 8
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
OTX-DP (Dexamethasone Punctum Plug)ACTIVE_COMPARATORResorbable hydrogel drug delivery vehicle containing dexamethasone
PVPP (Placebo Punctum Plug)PLACEBO_COMPARATORResorbable hydrogel drug delivery vehicle containing no drug
Interventions
NameTypeDescription
DexamethasoneDRUG -
Punctum PlugDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Has a cataract and is expected to undergo clear corneal cataract surgery with phacoemulsification and implantation of a posterior chamber intraocular lens * Has a potential post-operative pinhole corrected Snellen VA of at least 20/200 or better in both eyes Exclusion Criteri...

Countries:United States
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