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TAP311

Phase 1

Dyslipidaemia | Small molecule | Metabolic |Novartis AG|Last Updated: Dec 2, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
Double-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment279
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01632358Safety and Pharmacokinetis of TAP311 in Dyslipidemic PatientsPHASE1 COMPLETED 279Jun 1, 2012Dec 1, 2012Dec 2, 20133 United States, Jordan +1
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Study Endpoints
Primary Endpoints
Number of patients with adverse events
14 days after treatment

Summary statistics on number of patients with total adverse events, serious adverse events and death will be reported.

Secondary Endpoints
Pharmacokinetics of TAP311: The observed maximum plasma concentration following drug administration at steady state (Cmax,ss)
Day 1 and Day 14
Pharmacokinetics of TAP311: The time to reach the maximum concentration after drug administration at steady state(Tmax, ss)
Day 1 and Day 14 profile
Pharmacokinetics of TAP311: The area under the plasma concentration-time curve from time zero to the time of the last quantifiable concentration (AUClast)
Day 1
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Study Design & Arms
MaskingQUADRUPLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
TAP311 capsulesEXPERIMENTALPatients will receive TAP311 capsule orally once daily for 14 days.
Placebo of TAP311 capsulesPLACEBO_COMPARATORMatching placebo to TAP311 capsule, once daily for 14 days
Interventions
NameTypeDescription
TAP311 capsulesDRUG -
PlaceboDRUG -
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Eligibility Criteria
Age Range18 Years — 80 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Male and female patients 18 to 80 years (inclusive) of age. * Patients are not treated for dyslipidemia with medications other than HMG-CoA reductase inhibitors (statins) for at least 4 weeks prior to Day 1. Patients should be on stable doses of current medications, if any, fo...

Countries:United StatesJordanTaiwan
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