Recent Updates
Recently added Catalysts

QCC374

Phase 1

Healthy Subjects | Small molecule | Other |Novartis AG|Last Updated: Mar 22, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment66
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02245828A First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of QCC374PHASE1 COMPLETED 66Jul 1, 2014Dec 1, 2015Mar 22, 20161 United Kingdom
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Safety and tolerability
39 days

Number of Participants with Adverse Events

Secondary Endpoints
AUCinf
39 days
AUClast
39 days
AUCtau
39 days
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PlaceboPLACEBO_COMPARATORPlacebo comparator
QCC374EXPERIMENTALSingle and multiple ascending doses of QCC374
Interventions
NameTypeDescription
QCC374DRUGSingle and multiple ascending doses of QCC374
PlaceboDRUGPlacebo comparator
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Written informed consent must be obtained before any assessment is performed. 2. Healthy male and female subjects age 18 to 55 years of age included, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory...

Countries:United Kingdom
Unlock Eligibility Criteria