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QAT370

Phase 1

Chronic Obstructive Pulmonary Disease | Small molecule | Respiratory |Novartis AG|Last Updated: Dec 19, 2020

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment22

FDA Designations

No designations recorded

Clinical trial landscape

QAT370 · 1 trial · 1 indication

Phase 1 1
NCT00532350Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary DiseaseChronic Obstructive Pulmonary Disease
COMPLETED22 Analytics
PHASE1COMPLETED
Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Forced expiratory volume in 1 second
Days 1 and 7

Secondary Endpoints

Forced expiratory volume in 1 second and corresponding parameters for inspiratory capacity.
Days 1 and 7
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTALQAT370
2PLACEBO_COMPARATORPlacebo
3ACTIVE_COMPARATORTiotropium

Interventions

NameTypeDescription
QAT370DRUG -
PlaceboDRUG -
TiotropiumDRUG -
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Eligibility Criteria

Age Range40 Years to 80 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Patients between 40 and 80 years of age with controlled COPD. * Women must be surgically sterilized or postmenopausal. Additional birth control and post-menopausal information will be available at time of enrollment. * Body mass index (BMI) must be within the range of 18 to 32...

Countries:Germany
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Frequently asked questions about QAT370

What is QAT370 used for in Chronic Obstructive Pulmonary Disease?

QAT370 is an investigational small molecule being developed by Novartis AG for the treatment of Chronic Obstructive Pulmonary Disease (COPD). It is currently in Phase 1 clinical development, meaning it has not yet been approved and is still being studied for safety and tolerability in patients.

What does QAT370 target?

The molecular target of QAT370 has not been disclosed. It is a small molecule being studied for its safety and tolerability in patients with Chronic Obstructive Pulmonary Disease, but its specific mechanism of action is not publicly available.

Who makes QAT370?

QAT370 is being developed by Novartis AG, a multinational pharmaceutical company traded on the New York Stock Exchange under the ticker symbol NVS. The drug is currently in Phase 1 clinical trials for Chronic Obstructive Pulmonary Disease.

What phase is QAT370 in?

QAT370 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. A Phase 1 trial has been completed, but the drug remains in early-stage clinical testing for Chronic Obstructive Pulmonary Disease.

What clinical trials is QAT370 in?

QAT370 has one completed Phase 1 clinical trial registered as NCT00532350, titled "Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease." The trial enrolled 22 participants in Germany and was a randomized, double-blind, placebo-controlled study.

Is QAT370 the same as tiotropium?

No, QAT370 is not the same as tiotropium. In the Phase 1 clinical trial NCT00532350, QAT370 was compared to tiotropium, which is an approved treatment for Chronic Obstructive Pulmonary Disease. QAT370 is a separate investigational drug being studied for the same condition.