Recent Updates
Recently added Catalysts

Meningococcal Vaccine

Phase 2

Meningococcal Disease | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Oct 24, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment495
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01210885Immunogenicity and Safety of Different rMenB Plus MenACWY Formulations in AdolescentsPHASE2 COMPLETED 495Dec 1, 2010Jul 1, 2011Oct 24, 20118 Chile, Colombia +1
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Serum Bactericidal Assay (SBA) Geometric Mean Titers (GMTs)
3 months
Percentage of subjects with seroresponse, and human Serum Bactericidal Activity (hSBA) titer ≥ 1:8 and hSBA titer ≥ 1:4 to Neisseria meningitidis serogroups A, C, W-135 and Y
3 months
Percentage of subjects with hSBA titer ≥ 1:5 to N. meningitidis serogroup B strains
3 months
Number of participants with solicited local and systemic reactions
within 7 days after each vaccination
Number of participants with any adverse events (AEs)
6 months
Number of participants with Serious Adverse Events (SAEs)
3 months
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group I: Investigational MenABCWY Formulation 1EXPERIMENTAL -
Group II: Investigational MenABCWY Formulation 2EXPERIMENTAL -
Group III: Investigational MenABCWY Formulation 3EXPERIMENTAL -
Group IV: Investigational MenABCWY Formulation 4EXPERIMENTAL -
Group V: Active comparator investigational MenBACTIVE_COMPARATOR -
Group VI: Active comparator MenACWYACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Meningococcal VaccineBIOLOGICALMenABCWY combination vaccine containing four different rMenB formulations with MenACWY, intramuscular (IM) administration, vaccination at 0 and 2 months.
Unlock Study Design Details
Eligibility Criteria
Age Range11 Years — 18 Years
SexALL
Healthy VolunteersYes
Study Sites8

Inclusion Criteria: Individuals eligible to be enrolled into this study are male and female subjects: 1. 11-18 years at the time of enrollment; 2. who have given their written consent/assent and whose parents or legal guardians have given written informed consent at the time of enrollment; 3. who ...

Countries:ChileColombiaPanama
Unlock Eligibility Criteria