Recent Updates
Recently added Catalysts

HSP990

Phase 1

Advanced Solid Malignancies | Small molecule | Other |Novartis AG|Last Updated: Dec 8, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
CONTROLLEDBiomarker
Total Trials1
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00879905A Study of HSP990 Administered by Mouth in Adult Patients With Advanced Solid TumorsPHASE1 COMPLETED 64May 1, 2009Jul 1, 2012Dec 8, 20203 Canada, France +1
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Maximum Tolerated Dose of HSP990 in patients treated once weekly or twice weekly
At the end of the dose escalation phase of the study
Secondary Endpoints
True DLT rate
At the end of the 1st 4 weeks of treatment
Preliminary Efficacy
Every 2 months (or 8 weeks, which equals 2 treatment cycles)
Drug metabolism in Humans, PK, PD
every 4 weeks
Unlock Study Endpoints
Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
once weekly dosing scheduleEXPERIMENTAL -
twice weekly dosing scheduleEXPERIMENTAL -
Interventions
NameTypeDescription
HSP990DRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: 1. Patients with histologically confirmed, advanced malignant solid tumors whose disease has progressed on standard therapy or for whom no standard therapy exists 2. All patients must have at least one measurable lesion as defined by RECIST. Irradiated lesions are only evaluable...

Countries:CanadaFranceSpain
Unlock Eligibility Criteria