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H5N1 Influenza Vaccine

Phase 2

Prophylaxis of Avian Influenza | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Dec 1, 2016

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment471

FDA Designations

No designations recorded

Clinical trial landscape

H5N1 Influenza Vaccine · 2 trials · 2 indications

Phase 2 2
NCT00561184Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza VaccineAvian Influenza
COMPLETED47 Analytics
NCT00537524Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 YearsProphylaxis of Avian Influenza
COMPLETED471 Analytics
PHASE2COMPLETED
Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine
Avian InfluenzaUnlock trial analytics
PHASE2COMPLETED
Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years
Prophylaxis of Avian InfluenzaUnlock trial analytics

Study Endpoints

Primary Endpoints

Number and percentage of subjects with at least one local reaction between 1 and 7 days after vaccination.
7 days
Number and percentage of subjects with at least one systemic reaction between 1 and 7 days after vaccination.
7 days
safety and tolerability of, and magnitude of antibody responses to two 0.5mL intramuscular injections of an H5N1 influenza vaccineapart
administered 3 weeks apart

Secondary Endpoints

Number and percentage of subjects with at least one adverse event between day of vaccination and the study termination visit.Safety will be assessed in accordance with available safety data on influenza vaccines.
8 months
safety and tolerability of, and magnitude of antibodies to one booster dose with a H5N1
12 months after primary immunization
safety profile of a H5N1 compared to a seasonal flu vaccinepersistence of specific antibodies
12 months after primary immunization
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION

Treatment Arms

ArmTypeDescription
1EXPERIMENTAL -
2EXPERIMENTAL -
Arm 1EXPERIMENTAL0.5mL of H5N1 vaccine 7.5ug
Arm 2ACTIVE_COMPARATOR0.25 or 0.5mL of H5N1 vaccine

Interventions

NameTypeDescription
H5N1 influenza vaccineBIOLOGICALOne 0.5 ml booster injection 12 months after the second injection, of influenza vaccine containing 7.5 micrograms of H5N1 influenza antigen
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Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion Criteria: * Healthy subjects who previously participated in study V87P1, but did not receive the booster dose on day 202 Exclusion Criteria: * Pregnant or breastfeeding * Receipt of another vaccine or any investigational agent within the past 4 weeks * Surgery planned during the study p...

Countries:ItalyFinland
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Frequently asked questions about H5N1 Influenza Vaccine

What is H5N1 Influenza Vaccine used for?

H5N1 Influenza Vaccine is used for prophylaxis of avian influenza, also known as bird flu, and for the prevention of avian influenza infection. It is an investigational vaccine being developed to protect against the H5N1 influenza virus strain.

Who makes H5N1 Influenza Vaccine?

H5N1 Influenza Vaccine is being developed by Novartis AG, a multinational pharmaceutical company traded on the New York Stock Exchange under the ticker symbol NVS. The vaccine is currently in clinical development for the prevention of avian influenza.

What phase is H5N1 Influenza Vaccine in?

H5N1 Influenza Vaccine is in Phase 2 clinical development. It is an investigational vaccine and has not been approved by regulatory authorities. Clinical trials are ongoing to evaluate its safety and immunogenicity in various age groups.

What clinical trials is H5N1 Influenza Vaccine in?

H5N1 Influenza Vaccine has been studied in two completed Phase 2 clinical trials. NCT00537524 evaluated two doses of the vaccine in participants aged 6 months to 17 years in Finland, enrolling 471 participants. NCT00561184 assessed a booster dose in adults aged 18 years and older in Italy, enrolling 47 participants.

Is H5N1 Influenza Vaccine a monoclonal antibody?

Yes, H5N1 Influenza Vaccine is classified as a monoclonal antibody modality. It is being developed as a vaccine for avian influenza prophylaxis, with clinical trials assessing its immunogenicity, safety, and tolerability in healthy volunteers.