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H5N1 Influenza Vaccine

Phase 2

Prophylaxis of Avian Influenza | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Feb 16, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment471
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00537524Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 YearsPHASE2 COMPLETED 471Sep 1, 2007May 1, 2008Feb 16, 20121 Finland
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Study Endpoints
Primary Endpoints
safety and tolerability of, and magnitude of antibody responses to two 0.5mL intramuscular injections of an H5N1 influenza vaccineapart
administered 3 weeks apart
Secondary Endpoints
safety and tolerability of, and magnitude of antibodies to one booster dose with a H5N1
12 months after primary immunization
safety profile of a H5N1 compared to a seasonal flu vaccinepersistence of specific antibodies
12 months after primary immunization
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Arm 1EXPERIMENTAL0.5mL of H5N1 vaccine 7.5ug
Arm 2ACTIVE_COMPARATOR0.25 or 0.5mL of H5N1 vaccine
Interventions
NameTypeDescription
H5N1 Influenza VaccineBIOLOGICALTwo 0.5mL injections of H5N1 influenza vaccine containing 7.5μg of H5N1 antigen (A/Vietnam/1194/2004), administered 3 weeks apart, and one 0.5mL injection of H5N1 vaccine 12 months after the second dose, IM into the deltoid muscle (preferably of the non-dominant arm) or anterolateral thigh (depending on the muscle mass).
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Eligibility Criteria
Age Range6 Months — 17 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy subjects Exclusion Criteria: * Receipt of Seasonal Influenza Vaccine for season 2007/2008 * Receipt of another vaccine within 3 weeks before and after each vaccination * Previous vaccination with a pandemic candidate vaccine and/or vaccine containing the adjuvant MF5...

Countries:Finland
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