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GP2013

Phase 3

Follicular Lymphoma | Monoclonal antibody | Oncology |Novartis AG|Last Updated: May 14, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment629
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01419665GP2013 in the Treatment of Patients With Previously Untreated, Advanced Stage Follicular Lymphoma (ASSIST_FL)PHASE3 COMPLETED 629Dec 1, 2011Jan 22, 2018May 14, 2021153 Argentina, Australia +24
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Study Endpoints
Primary Endpoints
Overall Response Rate (ORR)
24 weeks

ORR is defined as the proportion of patients whose best overall disease response was either CR or PR during the combination treatment period based on blinded independent central radiology review.

Secondary Endpoints
To Evaluate the Complete Response (CR) Rate During the Combination Treatment Period
24 weeks
To Evaluate the Partial Response (PR) Rate During the Combination Treatment Period
24 weeks
To Evaluate the Progression Free Survival (PFS) With up to 3 Years of Follow-up Post Randomization
3 years
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
GP2013EXPERIMENTALType: Biological/Vaccine
rituximabACTIVE_COMPARATORType: Biological/Vaccine
Interventions
NameTypeDescription
GP2013BIOLOGICALType: Biological/Vaccine
rituximabBIOLOGICALType: Biological/Vaccine
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites153

Inclusion Criteria: * Patient with previously untreated advanced stage, CD20-positive FL * Patient with ECOG performance status 0, 1 or 2. Exclusion Criteria: * Patient with Grade 3b (aggressive) FL or any histology other than FL grade 1, 2 or 3a * Patient who has previously received any prior th...

Countries:ArgentinaAustraliaAustriaBrazilBulgariaColombiaFranceGermanyGreeceHungaryIndiaIrelandIsraelItalyJapanMalaysiaNetherlandsPeruPolandPortugalRomaniaRussiaSouth AfricaSpainUkraineUnited Kingdom
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