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Fluad H5N1 Pandemic Influenza Vaccine

Phase 2

Prophylaxis of Avian Influenza Vaccine | Monoclonal antibody | Infectious Disease |Novartis AG|Last Updated: Dec 1, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
ACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment58
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00478816Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza VaccinesPHASE2 COMPLETED 58May 1, 2007Feb 1, 2009Dec 1, 20161 United Kingdom
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Study Endpoints
Primary Endpoints
Cell-mediated immunity, magnitude, breath and kinetics of antibody response to 2 doses of MF59-adjuvanted H5N1 influenza vaccine, in subjects primed by previous vaccination with either MF59-adjuvanted or non-adjuvanted H5N3 influenza vaccine.
Days 1, 8, 15, 22, 43 and 202
Secondary Endpoints
Safety Objectives: safety and reactogenicity of the vaccine
Days 1, 8, 15, 22, 43 and 202
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group 1ACTIVE_COMPARATORPrimed subject with pandemic Vaccine
Group 2ACTIVE_COMPARATORNon Primed subject with pandemic Vaccine
Interventions
NameTypeDescription
Fluad H5N1 Pandemic Influenza VaccineBIOLOGICALTwo 0.5 mL doses of MF59-adjuvanted A/Vietnam/1194/2004 (H5N1 Clade 1) hemagglutinin (HA) subvirion influenza vaccine, containing 7.5 μg of H5N1 antigen,administered 3 weeks apart, IM in the deltoid muscle, preferably of the non-dominant arm.
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Subjects aged 18 to 65 years of age, mentally competent, who have signed an informed consent form after having received a detailed explanation of the study protocol; 2. In good health as determined by: 1. medical history, 2. physical examination, 3. clinical judgmen...

Countries:United Kingdom
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