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Ferric carboxymaltose

Phase 1

Iron Deficiency Anemia | Small molecule | Hematology |Novartis AG|Last Updated: May 30, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment71
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03399084A Study Comparing Two Ferric Carboxymaltose Formulations in Patients With Iron Deficiency AnemiaPHASE1 COMPLETED 71Nov 29, 2017Jan 15, 2019May 30, 20191 United States
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Study Endpoints
Primary Endpoints
Bioequivalence assessed by maximum serum concentration (Cmax)of serum total iron.
Up to 7 days

Measured by Cmax - The maximum plasma concentration of iron

Bioequivalence assessed by area under the serum concentration-time curve (AUC) of serum total iron.
Up to 7 Days

Plasma Pharmacokinetics (PK) of study medication: Area Under the Plasma Concentration-time Curve (AUC)

Secondary Endpoints
Maximum serum concentration (Cmax) of serum transferrin-bound iron.
Up to 7 days
Time of Cmax (Tmax) of serum total iron and transferrin-bound iron
Up to 7 Days
Area under the serum concentration-time curve (AUC) of serum transferrin-bound iron
Up to 7 Days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeOTHER
Treatment Arms
ArmTypeDescription
Ferric carboxymaltose (test)EXPERIMENTALPatients will receive a single dose of Ferric carboxymaltose
Ferric carboxymaltose (reference)ACTIVE_COMPARATORPatients will receive a single dose of Ferric carboxymaltose
Interventions
NameTypeDescription
Ferric carboxymaltoseDRUG750 mg/15 mL
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Male and female patients at least 18 - 65 years of age; * Patients with a body mass index (BMI) between 18.5 - 35 and with a body weight of ≥50 kg - ≤130 kg; Exclusion Criteria: * Patients with known hypersensitivity to ferric carboxymaltose, excipients, or similar product *...

Countries:United States
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