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EP2006

Phase 3

Chemotherapy Associated Neutropenia | Small molecule | Oncology |Novartis AG|Last Updated: May 6, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment218
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01519700Phase III Study Comparing the Efficacy and Safety of EP2006 and FilgrastimPHASE3 COMPLETED 218Dec 1, 2011Jun 1, 2013May 6, 201526 Czechia, Hungary +4
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Study Endpoints
Primary Endpoints
Mean Duration of Grade 4 Neutropenia During Cycle 1 of Chemotherapy
21 days (Cycle 1 of chemotherapy treatment)

Mean duration of severe neutropenia, defined as the mean number of consecutive days with Grade 4 neutropenia (ANC less than 0.5\*10\^9 cells/L)

Secondary Endpoints
Incidence of Febrile Neutropenia
21 weeks/ 6 cycles
Number of Days of Fever
21 weeks/ 6 cycles
Depth of Absolute Neutrophil Count Nadir
Cycle 1/ 21 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeSUPPORTIVE_CARE
Treatment Arms
ArmTypeDescription
EP2006EXPERIMENTALEligible patients will be teated with EP2006
FilgrastimACTIVE_COMPARATOREligible patients will be teated with Filgrastim
Interventions
NameTypeDescription
EP2006DRUGEligible patients will be teated with EP2006
FilgrastimDRUGEligible patients will be teated with Filgrastim
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Eligibility Criteria
Age Range18 Years — N/A
SexFEMALE
Healthy VolunteersNo
Study Sites26

Inclusion Criteria: 1. Patients with histologically proven breast cancer, eligible for neoadjuvant or adjuvant myelosuppressive chemotherapy 2. Women ≥ 18 years of age 3. Estimated life expectancy of more than six months Exclusion Criteria: 1. Previous or concurrent malignancy except non-invasive...

Countries:CzechiaHungaryLatviaRussiaSlovakiaUkraine
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