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EDI048

Phase 1

Healthy Volunteers | Small molecule | Other |Novartis AG|Last Updated: Jan 10, 2025

Success Probability
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Market & Valuation
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Trial Design
RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment110
FDA Designations
No designations recorded
Clinical trial landscape

EDI048 · 1 trial · 1 indication

Phase 1 1
NCT05275855First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of EDI048 in Healthy VolunteersHealthy Volunteers
COMPLETED110 Analytics
PHASE1COMPLETED
First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of EDI048 in Healthy Volunteers
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Study Endpoints
Primary Endpoints
Number of participants with Adverse Events (AEs)
From the start of treatment to 30 days after end of treatment, assessed up to maximum duration of 8.5 weeks for Part A and 9 weeks for Part B

Number of participants with AEs and Serious Adverse Events (AEs), including significant changes from baseline in vital signs, electrocardiograms and laboratory assessments qualifying and reported as AEs.

Secondary Endpoints
Parts A and B: Cmax
up to 13 days
Parts A and B: Tmax
up to 13 days
Parts A and B: AUClast
up to 13 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Part A: EDI048 or PlaceboEXPERIMENTALPart A is a single ascending dose study
Part B: EDI048 or PlaceboEXPERIMENTALPart B is a multiple ascending dose study
Interventions
NameTypeDescription
EDI048DRUGOral Liquid
PlaceboOTHEROral Liquid
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Eligibility Criteria
Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and female participants 18 to 55 years of age included, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening. * Participants must weigh at least 50 kg to participate in th...

Countries:United Kingdom
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