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Cefprozil

Phase 1

Healthy | Small molecule | Other |Novartis AG|Last Updated: Mar 29, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment61
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00881426To Demonstrate the Relative Bioavailability of Cefzil 500 mg Cefprozil Tablets Under Fasting ConditionsPHASE1 COMPLETED 26Mar 1, 2004Apr 1, 2004Mar 29, 2017 -
NCT00881855To Demonstrate the Relative Bioavailability of Cefzil 500 mg Cefprozil Tablets Under Fed ConditionsPHASE1 COMPLETED 35Mar 1, 2004Apr 1, 2004Mar 29, 2017 -
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Study Endpoints
Primary Endpoints
Bioequivalence based on AUC and Cmax
16 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALCefprozil 500 mg Tablets (Sandoz GmbH)
2ACTIVE_COMPARATORCefzil (Cefprozil) 500 mg Tablets (Bristol-Myers Squibb)
Interventions
NameTypeDescription
Cefprozil 500 mg Tablets (Sandoz GmbH)DRUG -
Cefzil (Cefprozil) 500 mg Tablets (Bristol-Myers Squibb)DRUG -
Cefprozil 500 mg Tablets (Sandoz, GmbH)DRUG -
Cefzil (Cefprozil) 500 mg Tablets (Bristol-Myers Squibb, USA)DRUG -
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Eligibility Criteria
Age Range20 Years — 54 Years
SexALL
Healthy VolunteersYes

Inclusion Criteria: * No clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. Exclusion Criteria: * Positive test results for HIV or hepatitis B or C. * Treatment for drug or alcohol dependence.

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