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Canakinumab in prefilled syringe

Phase 3

Acute Gouty Arthritis | Small molecule | Musculoskeletal |Novartis AG|Last Updated: Jul 19, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment397
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01431638Long-Term Safety and Tolerability of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis PatientsPHASE3 COMPLETED 397Aug 25, 2011May 9, 2013Jul 19, 202168 United States, Canada +2
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Study Endpoints
Primary Endpoints
Number of Participants Who Reported Adverse Events
From start of the core study (CACZ885H2361 [NCT01356602]) upto end of the current study (48 weeks)
Secondary Endpoints
Probability of New Gout Flares at End of Study
Up to Day 337
Number of Participant With New Flares
up to 36 weeks
Change From Baseline in Pain Intensity on a 5-point Likert Scale
Baseline, upto 14 days post-dose
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Canakinumab 150mgEXPERIMENTALCanakinumab 150mg in prefilled syringe subcutaneously
Interventions
NameTypeDescription
Canakinumab 150mg in prefilled syringeDRUGCanakinumab 150mg in prefilled syringe will be given in a single dose subcutaneously upon demand for gouty arthritis flares
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Eligibility Criteria
Age Range18 Years — 85 Years
SexALL
Healthy VolunteersNo
Study Sites68

Inclusion criteria: * Compliance and completion of the canakinumab PFS core study * Unchanged significant clinical medical history from entry into core study Exclusion criteria: * Physician judgment of unsuitability for the study * Pregnant or nursing women Other protocol-defined inclusion/exclus...

Countries:United StatesCanadaGermanyLithuania
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