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BPR277

Phase 1

Healthy Volunteers | Small molecule | Rare Disease |Novartis AG|Last Updated: Dec 8, 2020

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

BPR277 · 1 trial · 3 indications

Phase 1 1
NCT01428297A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton SyndromeHealthy Volunteers
COMPLETED12 Analytics
PHASE1COMPLETED
A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome
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Study Endpoints

Primary Endpoints

Systemic and local tolerability of BPR277 ointment, as measured by change in local tolerability score, number of adverse events and clinically significant changes in standard hematology, blood chemistry.
2-4 weeks
Part 2 and 3: Patients with Atopic Dermatitis / Netherton syndrome: Change in Total Lesional Signs Score at the treated skin area
4 weeks

Secondary Endpoints

Part 2 and 3: Patients with Atopic Dermatitis / Netherton syndrome: Change for each sign comprising the total lesional signs score at the treated skin area
4 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Cohort A and B, BPR277 and Placebo (vehicle)EXPERIMENTAL -
Part 2 BPR277EXPERIMENTAL -
Part 2 Placebo (vehicle)PLACEBO_COMPARATOR -
Part 3 BPR277 and Placebo (vehicle)EXPERIMENTAL -

Interventions

NameTypeDescription
BPR277 ointment (controlled application)DRUG -
Placebo (Vehicle)DRUG -
BPR277 ointmentDRUG -
BPR277DRUG -
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites4

Inclusion Criteria: Part 1 Healthy volunteers * Healthy male and female subjects of non childbearing potential, 18 to 65 years of age inclusive and in good health Part 2 Patients with atopic dermatitis: * Male and female subjects, 18 to 65 years of age inclusive and having passed screening exami...

Countries:United StatesNetherlands
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Frequently asked questions about BPR277

What is BPR277?

BPR277 is an investigational small molecule being developed by Novartis AG (NVS) for the treatment of atopic dermatitis and Netherton syndrome. It is currently in Phase 1 clinical development and has been studied in healthy volunteers. BPR277 is being evaluated as a topical treatment for these skin conditions.

What is BPR277 used for?

BPR277 is being studied for the treatment of atopic dermatitis and Netherton syndrome. It is administered topically and has been evaluated in a Phase 1 clinical trial involving healthy volunteers, as well as patients with these conditions. The drug is still in early-stage clinical development and is not yet approved.

Who makes BPR277?

BPR277 is being developed by Novartis AG, a multinational pharmaceutical company listed on the stock exchange under the ticker symbol NVS. Novartis is conducting clinical trials to evaluate the safety and efficacy of BPR277 for the treatment of atopic dermatitis and Netherton syndrome.

What phase is BPR277 in?

BPR277 is in Phase 1 clinical development. A Phase 1 trial has been completed, which evaluated the safety and efficacy of topical BPR277 in healthy volunteers and patients with atopic dermatitis and Netherton syndrome. The drug is investigational and has not yet received regulatory approval.

What clinical trials is BPR277 in?

BPR277 has been studied in one completed Phase 1 clinical trial with the identifier NCT01428297. This trial evaluated the safety and efficacy of topical BPR277 for the treatment of atopic dermatitis and Netherton syndrome. The study enrolled 12 participants and was conducted in the United States and the Netherlands.

Is BPR277 the same as any other drug?

No alternative names for BPR277 have been reported. The drug is identified solely by its code name BPR277 in clinical trials and development records. It is being developed by Novartis AG for the treatment of atopic dermatitis and Netherton syndrome.