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Angiomax anticoagulant

Phase 3

Myocardial Infarction | Small molecule | Cardiovascular |Novartis AG|Last Updated: Nov 30, 2018

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment300

FDA Designations

No designations recorded

Clinical trial landscape

Angiomax anticoagulant · 3 trials · 7 indications

Phase 3 3
NCT00093184Bivalirudin in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary PCIMyocardial Infarction
COMPLETED300 Analytics
NCT00073580Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE)Thrombocytopenia
COMPLETED88 Analytics
NCT00093158Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS)Unstable Angina
COMPLETED13,800 Analytics
PHASE3COMPLETED
Bivalirudin in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary PCI
Myocardial InfarctionUnlock trial analytics
PHASE3COMPLETED
Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE)
ThrombocytopeniaUnlock trial analytics
PHASE3COMPLETED
Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS)
Unstable AnginaUnlock trial analytics

Study Endpoints

Primary Endpoints

Reduction in bleeding complications
Primary Endpoint
7 days

: In-hospital acute procedural success, defined as the absence of death, Q wave myocardial infarction (MI), repeat coronary revascularization, and stroke (hemorrhagic or ischemic) at hospital discharge or Day 7 after surgery ('Day 7/discharge'), whichever occurs first.

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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
Angiomax (bivalirudin) anticoagulantDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Patients \>18 years of age. 2. Symptoms of STEMI for at least 30 min within previous 12 hours AND * ST-segment elevation in at least 2 contiguous leads or new Left Branch Bundle Block (LBBB), OR existing LBBB with positive troponin * Residual high grade stenosis and as...

Countries:United States
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Frequently asked questions about Angiomax anticoagulant

What is Angiomax used for?

Angiomax is used for thrombocytopenia, unstable angina, and myocardial infarction. It is a small molecule cardiovascular drug being developed by Novartis AG. Angiomax is also studied in conditions like thrombosis, cardiac disease, and coronary artery bypass surgery.

What does Angiomax target?

Angiomax is a small molecule anticoagulant. It targets thrombin, a key enzyme in the blood clotting process. By inhibiting thrombin, Angiomax helps prevent blood clots in patients with cardiovascular conditions.

Who makes Angiomax?

Angiomax is developed by Novartis AG, a multinational pharmaceutical company. Novartis is listed on the stock exchange under the ticker symbol NVS.

What phase is Angiomax in?

Angiomax is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. All three completed trials for Angiomax were Phase 3 studies.

What clinical trials is Angiomax in?

Angiomax has completed three Phase 3 clinical trials. These include NCT00073580 for thrombocytopenia and thrombosis in coronary artery bypass surgery, NCT00093158 for unstable angina and myocardial infarction, and NCT00093184 for acute myocardial infarction undergoing primary PCI.

Is Angiomax the same as bivalirudin?

Angiomax is also known as bivalirudin. The clinical trial NCT00093184 specifically refers to bivalirudin in patients with acute myocardial infarction undergoing primary PCI, confirming that Angiomax and bivalirudin are the same drug.