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AHT956

Phase 1

Undisclosed | Small molecule | Other |Novartis AG|Trials Updated: Jun 22, 2007

AHT956 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Dec 2006

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment42

FDA Designations

No designations recorded

AHT956 clinical trials

AHT956 · 1 trial · 1 indication

Phase 1 1
NCT00410228Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AHT956 in Healthy SubjectsHealthy
COMPLETED42 Analytics
PHASE1COMPLETED
Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AHT956 in Healthy Subjects
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Study Endpoints

Primary Endpoints

Safety, tolerability of ascending single doses of AHT956 in healthy subjects
MTD (Maximum Tolerated Dose)

Secondary Endpoints

Pharmacokinetics of single oral doses of AEB071
Inhibition of T-cell function and lymphocytes proliferation following single rising oral of AHT956
Pharmacokinetic/pharmacodynamic relationship of single rising oral doses of AHT956 at the end of study
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
AHT956DRUG -
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Eligibility Criteria

Age Range18 Years to 45 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and female subjects age 18 to 45 years of age included, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening. * Vital signs must be within the following ranges: oral body ...

Countries:Switzerland
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Frequently asked questions about AHT956

What is AHT956?

AHT956 is an investigational small molecule developed by Novartis AG. It has been studied in a Phase 1 clinical trial in healthy adult volunteers, and no therapeutic indication has been disclosed for the compound. It is not an approved medicine and remains in early clinical development.

Who is developing AHT956?

AHT956 is being developed by Novartis AG, which trades under the ticker NVS. Novartis sponsored the Phase 1 study of the compound conducted in Switzerland. No partnership or licensing arrangement for AHT956 has been announced.

What phase is AHT956 in?

AHT956 is in Phase 1 development. One Phase 1 trial has been completed, and no active trials are currently listed. Because only early-stage testing has been conducted, AHT956 is investigational and has not been approved by the FDA or any other regulatory authority.

What clinical trials has AHT956 been studied in?

AHT956 has been evaluated in one completed Phase 1 trial, NCT00410228, titled "Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AHT956 in Healthy Subjects." The study enrolled 42 healthy adult volunteers in Switzerland and used a randomized, double-blind design.

How was the AHT956 Phase 1 trial designed?

The AHT956 Phase 1 trial, NCT00410228, was a randomized, double-blind study of oral AHT956 in 42 healthy volunteers aged 18 years and older in Switzerland. It assessed safety, tolerability, pharmacokinetics and pharmacodynamics. The study is listed as completed and enrolled healthy participants rather than patients with a specific disease.