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biphasic human insulin 30

Phase 1

Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Mar 1, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials2
Total Enrollment79
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01486888Bioequivalence of Two Mixtard® 30 Formulations in Healthy SubjectsPHASE1 COMPLETED 45May 1, 2006Jul 1, 2006Mar 18, 20151 Germany
NCT01620450Comparison of Insulin Aspart Produced by Current Process and the NN2000 Process in Healthy JapanesePHASE1 COMPLETED 34Nov 20, 2004Feb 26, 2005Mar 1, 20171 Japan
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Study Endpoints
Primary Endpoints
Area under the serum insulin concentration-time curve (AUC 0-24 hours)
Maximum serum insulin concentration (Cmax)
Area under the curve of insulin aspart concentration (AUC IAsp, 0-16h)
From 0 to 16 hours after injection
Maximum insulin aspart concentration (Cmax IAsp)
Secondary Endpoints
Area under the serum insulin concentration-time curve (AUC 0-6 hours)
Area under the serum insulin concentration-time curve (AUC 6-24 hours)
Area under the serum insulin concentration-time curve (AUC 0-inifinity hours)
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Formulation AEXPERIMENTAL -
Formulation BACTIVE_COMPARATOR -
NN2000EXPERIMENTAL -
NN-X14ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
biphasic human insulin 30DRUGSingle dose of each formulation, administered subcutaneously (s.c., under the skin) on two separate dosing visits
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Considered generally healthy upon completion of medical history and physical examination as judged by the Investigator * Body Mass Index (BMI) between 18.0 and 27.0 kg/m\^2, inclusive * Non-smoker, defined as no nicotine consumption for at least one year * Fasting plasma gluco...

Countries:GermanyJapan
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