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NNC9733-0001

Phase 1

Healthy Volunteer | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jul 20, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment60

FDA Designations

No designations recorded

Clinical trial landscape

NNC9733-0001 · 1 trial · 2 indications

Phase 1 1
NCT07270731A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 DiabetesHealthy Volunteer
RECRUITING60 Analytics
PHASE1RECRUITING
A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 Diabetes
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Study Endpoints

Primary Endpoints

Number of treatment emergent adverse events (TEAEs)
From dosing (day 1) until end of study (EOS) visit (week 36)

Measured as number of events

Number of hypoglycaemic episodes
From dosing (day 1) until end of study (EOS) visit (week 36)

Measured as number of episodes

Secondary Endpoints

AUC0-last,SD: The area under the NNC9733-0001 plasma concentration-time curve from time zero to last measured concentration above LLQO after a single dose
From dosing (day 1) to 48 hours after dosing
Cmax: The maximum concentration of NNC9733-0001 in plasma
From dosing (day 1) to 48 hours after dosing
tmax, SD: The time from dose administration to maximum plasma concentration of NNC9733-0001
From dosing (day 1) to 48 hours after dosing
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC9733-0001EXPERIMENTALParticipants will be administered a single dose of NNC9733-0001 in a dose escalated manner.
PlaceboEXPERIMENTALParticipants will be administered a single dose of matching NNC9733-0001 placebo in a dose escalated manner.

Interventions

NameTypeDescription
NNC9733-0001DRUGAdministered a single dose of NNC9733-0001.
PlaceboDRUGAdministered a single dose of matching NNC9733-0001 placebo.
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Eligibility Criteria

Age Range18 Years to 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: All participants * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine eligibility for the study. * Male, or female of nonchildbearing potential ...

Countries:Germany
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Recent Changes (Last 90 Days)

MEDIUMJul 20, 2026NCT07270731Enrollment: 72 → 60
MEDIUMJul 20, 2026NCT07270731Enrollment: 72 → 60

Frequently asked questions about NNC9733-0001

What is NNC9733-0001 used for?

NNC9733-0001 is an investigational small molecule being developed by Novo Nordisk for metabolic conditions. It is currently in a Phase 1 clinical trial in healthy volunteers and participants with type 2 diabetes. The drug is not approved and remains in clinical development.

Who makes NNC9733-0001?

NNC9733-0001 is being developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker NVO. The company is conducting a Phase 1 trial of this investigational small molecule in Germany.

What phase is NNC9733-0001 in?

NNC9733-0001 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The ongoing trial is recruiting participants to evaluate the new medicine in healthy volunteers and those with type 2 diabetes.

What clinical trials is NNC9733-0001 in?

NNC9733-0001 is being studied in one active Phase 1 trial, identified as NCT07270731. This randomized, double-blind, controlled study is recruiting 60 participants in Germany, including healthy volunteers and individuals with type 2 diabetes, with a minimum age of 18 years.

Is NNC9733-0001 the same as any other drug?

NNC9733-0001 is the only name provided for this investigational drug. No alternative names have been reported for this small molecule being developed by Novo Nordisk for metabolic conditions.