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NNC9733-0001

Phase 1

Type 2 Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Trials Updated: Jul 20, 2026

NNC9733-0001 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Dec 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment60

FDA Designations

No designations recorded

NNC9733-0001 clinical trials

NNC9733-0001 · 1 trial · 2 indications

Phase 1 1
NCT07270731A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 DiabetesHealthy Volunteer
RECRUITING60 Analytics
PHASE1RECRUITING
A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 Diabetes
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Study Endpoints

Primary Endpoints

Number of treatment emergent adverse events (TEAEs)
From dosing (day 1) until end of study (EOS) visit (week 36)

Measured as number of events

Number of hypoglycaemic episodes
From dosing (day 1) until end of study (EOS) visit (week 36)

Measured as number of episodes

Secondary Endpoints

AUC0-last,SD: The area under the NNC9733-0001 plasma concentration-time curve from time zero to last measured concentration above LLQO after a single dose
From dosing (day 1) to 48 hours after dosing
Cmax: The maximum concentration of NNC9733-0001 in plasma
From dosing (day 1) to 48 hours after dosing
tmax, SD: The time from dose administration to maximum plasma concentration of NNC9733-0001
From dosing (day 1) to 48 hours after dosing
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC9733-0001EXPERIMENTALParticipants will be administered a single dose of NNC9733-0001 in a dose escalated manner.
PlaceboEXPERIMENTALParticipants will be administered a single dose of matching NNC9733-0001 placebo in a dose escalated manner.

Interventions

NameTypeDescription
NNC9733-0001DRUGAdministered a single dose of NNC9733-0001.
PlaceboDRUGAdministered a single dose of matching NNC9733-0001 placebo.
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Eligibility Criteria

Age Range18 Years to 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: All participants * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine eligibility for the study. * Male, or female of nonchildbearing potential ...

Countries:Germany
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Frequently asked questions about NNC9733-0001

What is NNC9733-0001?

NNC9733-0001 is an investigational small molecule medicine being developed by Novo Nordisk for the treatment of type 2 diabetes. It is in Phase 1 clinical development and has not been approved for any use. It is being studied in healthy volunteers and in participants with type 2 diabetes.

What is NNC9733-0001 used for in type 2 diabetes?

NNC9733-0001 is being studied as a potential treatment for type 2 diabetes. It is an investigational therapy in Phase 1 testing, so it is not yet available as a prescribed treatment. Research so far includes healthy volunteers alongside participants with type 2 diabetes.

Who is developing NNC9733-0001?

NNC9733-0001 is being developed by Novo Nordisk A/S, the Danish pharmaceutical company whose shares trade under the ticker NVO. Novo Nordisk is the sponsor of the clinical program for this small molecule candidate in type 2 diabetes.

What phase is NNC9733-0001 in?

NNC9733-0001 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulator. The program currently has one active trial, with no completed trials reported to date.

What clinical trials is NNC9733-0001 in?

NNC9733-0001 is being evaluated in a single Phase 1 trial, NCT07270731, titled a research study of NNC9733-0001 in healthy participants and participants with type 2 diabetes. The trial is recruiting, is randomized, double blind, and controlled, and is expected to enroll about 60 participants in Germany.