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NNC6989-0001

Phase 1

Overweight | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jul 29, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment132

FDA Designations

No designations recorded

Clinical trial landscape

NNC6989-0001 · 1 trial · 2 indications

Phase 1 1
NCT07437079A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or ObesityOverweight
RECRUITING132 Analytics
PHASE1RECRUITING
A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity
OverweightUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of treatment emergent adverse events (TEAE) - Part A
From time of dosing on Day1 until completion of the end of study visit (Day 7)

Measure in number of events.

Number of treatment emergent adverse events (TEAE) - Part B
From time of dosing on Day 1 until completion of the end of study visit (Day 14)

Measured in number of events

iAUCTG; The incremental area under the blood triglycerides concentration-time curve following meal test - Part C
Following meal test at Day -1, Day 1, Day 7 and Day 13

Measured in ratio

Secondary Endpoints

AUC; the area under the NNC6989-0001 plasma concentration-time curve - Part A
From pre-dose on Day 1 until completion of the end of study visit (Day 7)
Cmax; the maximum plasma concentration of NNC6989-0001 - Part A
From pre-dose on Day 1 until completion of the end of study visit (Day 7)
AUC; the area under the NNC6989-0001 plasma concentration-time curve - Part B
From pre-dose on Day 1 until completion of the end of study visit (Day 14)
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC6989-0001EXPERIMENTALParticipants receive the investigational drug NNC6989-0001
PlaceboPLACEBO_COMPARATORParticipants receive placebo matched in appearance to the active drug.

Interventions

NameTypeDescription
NNC6989-0001DRUGParticipants assigned to the active intervention receive NNC6989-0001
Placebo (NNC6989-0001)DRUGParticipants assigned to the placebo, receive placebo matched in appearance to the active drug.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male or female of non-childbearing potential. * Age 18-55 years (both inclusive) at the time of signing the informed consent. * Body mass index (BMI) (at screening) ≥ 25.0 and ≤ 34.9 kg/m\^2 for Part A (SAD part) and BMI (at screening) ≥ 25.0 and ≤ 39.9 kg/m\^2 for Part B (MAD...

Countries:United States
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Recent Changes (Last 90 Days)

MEDIUMJul 29, 2026NCT07437079Enrollment: 96 → 132
MEDIUMJul 29, 2026NCT07437079Enrollment: 96 → 132

Frequently asked questions about NNC6989-0001

What is NNC6989-0001 used for?

NNC6989-0001 is an investigational small molecule being developed for the treatment of overweight and obesity. It is currently in Phase 1 clinical development, with a study enrolling healthy people living with overweight or obesity to evaluate its safety.

Who makes NNC6989-0001?

NNC6989-0001 is being developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker NVO. The company is conducting a Phase 1 clinical trial to assess the safety of this investigational medicine.

What phase is NNC6989-0001 in?

NNC6989-0001 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. A Phase 1 trial is currently recruiting participants to evaluate its safety in healthy individuals with overweight or obesity.

What clinical trials is NNC6989-0001 in?

NNC6989-0001 is being studied in a Phase 1 clinical trial registered as NCT07437079. This randomized, double-blind, placebo-controlled study is recruiting 132 participants in the United States to assess the safety of the drug in healthy people living with overweight or obesity.

Is NNC6989-0001 the same as any other drug?

No alternative names for NNC6989-0001 have been identified. The drug is known by its code name NNC6989-0001 and is being developed by Novo Nordisk A/S for the treatment of overweight and obesity.