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NNC0721-8060

Phase 1

Overweight | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Sep 4, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment142

FDA Designations

No designations recorded

Clinical trial landscape

NNC0721-8060 · 1 trial · 2 indications

Phase 1 1
NCT07767175A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or ObesityOverweight
RECRUITING142 Analytics
PHASE1RECRUITING
A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity
OverweightUnlock trial analytics

Study Endpoints

Primary Endpoints

Part A: Number of treatment emergent adverse events (TEAE)
From Day 1 to Day 36

Measured as number of events.

Part B: Number of treatment emergent adverse events (TEAE)
From Day 1 to Day 57

Measured as number of events.

Part C: Change from baseline in body weight
From Day 1 to Day 85

Measured as percentage change in body weight.

Secondary Endpoints

Part A: AUC- Area under the NNC0721-8060 plasma concentration time-curve
From Day 1 to Day 36
Part A: Cmax- Maximum observed plasma concentration of NNC0721-8060
From Day 1 to Day 36
Part B: AUC- Area under the NNC0721-8060 plasma concentration time-curve
From Day 1 to Day 57
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC0721-8060EXPERIMENTALParticipants will receive subcutaneous injection of NNC0721-8060.
SemaglutideACTIVE_COMPARATORParticipants will receive subcutaneous injection of semaglutide.
PlaceboPLACEBO_COMPARATORParticipants will receive subcutaneous injection of placebo.

Interventions

NameTypeDescription
NNC0721-8060DRUGNNC0721-8060 will be administered subcutaneously.
SemaglutideDRUGSemaglutide will be administered subcutaneously.
PlaceboDRUGPlacebo will be administered subcutaneously.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Male or female (sex at birth). * Age 18-55 years (both inclusive) at the time of signing informed consent. * Body Mass Index (BMI) 27.0-34.9 kilograms per square metre (kg/m\^2) (both inclusive) at screening, with overweight due to excess adipose tissue as judged by the invest...

Countries:United States
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Recent Changes (Last 90 Days)

LOWSep 4, 2026NCT07767175Status: NOT_YET_RECRUITING → RECRUITING
LOWAug 17, 2026NCT07767175NEW_TRIAL: changed
LOWAug 17, 2026NCT07767175NEW_TRIAL: changed

Frequently asked questions about NNC0721-8060

What is NNC0721-8060 used for?

NNC0721-8060 is an investigational small molecule being developed for the treatment of overweight and obesity. It is currently in Phase 1 clinical development, with a first-in-human study planned to evaluate how it works in people living with overweight or obesity.

Who makes NNC0721-8060?

NNC0721-8060 is being developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker symbol NVO. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational drug.

What phase is NNC0721-8060 in?

NNC0721-8060 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still undergoing clinical trials to assess its safety and effectiveness in humans.

What clinical trials is NNC0721-8060 in?

NNC0721-8060 is being studied in a Phase 1 clinical trial with the identifier NCT07767175. This first-in-human study is designed to evaluate how the drug works in people with overweight or obesity, with an enrollment of 142 participants in the United States.

Is NNC0721-8060 the same as any other drug?

No alternative names for NNC0721-8060 have been disclosed. The drug is identified solely by its code name NNC0721-8060 in clinical trial registries and public information.