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NNC0642-1895

Phase 1

Undisclosed | Small Molecules | Other |Novo Nordisk A/S|Trials Updated: Oct 26, 2026

NNC0642-1895 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Sep 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment148

FDA Designations

No designations recorded

NNC0642-1895 clinical trials

NNC0642-1895 · 1 trial · 1 indication

Phase 1 1
NCT07829406A Study to See How Safe a New Medicine (NNC0642-1895) is in Healthy PeopleHealthy Volunteers
RECRUITING148 Analytics
PHASE1RECRUITING
A Study to See How Safe a New Medicine (NNC0642-1895) is in Healthy People
Healthy VolunteersUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of treatment emergent adverse events (TEAE)
From pre-dose (Day 1) to Day 66

Measured as number of events.

Secondary Endpoints

AUC0-∞; the area under the NNC0642-1895 serum concentration-time curve from time 0 to infinity after a single dose
From pre-dose (Day 1) to Day 66
Cmax; the observed maximum serum concentration of NNC0642-1895 after a single dose
From pre-dose (Day 1) to Day 66
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC0642-1895EXPERIMENTALParticipants will be administered a single dose of NNC0537-1482 intravenously.
PlaceboPLACEBO_COMPARATORParticipants will receive placebo matched to NNC0642-1895 intravenously.

Interventions

NameTypeDescription
NNC0642-1895DRUGNNC0642-1895 will be administered intravenously.
PlaceboDRUGPlacebo will be administered intravenously.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-55 years (both inclusive) at the time of signing the informed consent. * Body Mass Index (BMI) between 18.5 to 29.9 kilogram per square meter (kg/m\^2) (both inclusive) at screening * Consider...

Countries:United States
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Recent Changes (Last 90 Days)

LOWOct 26, 2026NCT07829406Status: NOT_YET_RECRUITING → RECRUITING
LOWOct 26, 2026NCT07829406Status: NOT_YET_RECRUITING → RECRUITING
LOWSep 21, 2026NCT07829406NEW_TRIAL: changed
LOWSep 21, 2026NCT07829406NEW_TRIAL: changed

Frequently asked questions about NNC0642-1895

What is NNC0642-1895?

NNC0642-1895 is an investigational small molecule drug being developed by Novo Nordisk A/S. It is in Phase 1 clinical development and is being studied in healthy volunteers. The specific disease or condition it is intended to treat has not been publicly disclosed.

Who makes NNC0642-1895?

NNC0642-1895 is being developed by Novo Nordisk A/S, which trades under the ticker NVO. Novo Nordisk is the sponsor of the clinical program for this investigational small molecule.

What phase is NNC0642-1895 in?

NNC0642-1895 is in Phase 1 clinical development. It is an investigational drug and is not approved for any use. Its only registered study is a Phase 1 trial in healthy volunteers that is currently recruiting participants.

What clinical trials is NNC0642-1895 in?

NNC0642-1895 is being studied in one clinical trial, NCT07829406, titled a study to see how safe a new medicine (NNC0642-1895) is in healthy people. The Phase 1 trial is recruiting 148 healthy adult volunteers in the United States and is randomized, double-blind, and placebo-controlled.

What is the NCT07829406 trial of NNC0642-1895 testing?

NCT07829406 is a Phase 1 study evaluating the safety of NNC0642-1895 in healthy volunteers. It is a randomized, double-blind, placebo-controlled trial enrolling 148 participants aged 18 years and older in the United States, and it is currently recruiting.