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NNC0642-1895

Phase 1

Healthy Volunteers | Small molecule | Other |Novo Nordisk A/S|Last Updated: Sep 21, 2026

Development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Sep 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment148

FDA Designations

No designations recorded

Clinical trial landscape

NNC0642-1895 · 1 trial · 1 indication

Phase 1 1
NCT07829406A Study to See How Safe a New Medicine (NNC0642-1895) is in Healthy PeopleHealthy Volunteers
NOT YET_RECRUITING148 Analytics
PHASE1NOT YET_RECRUITING
A Study to See How Safe a New Medicine (NNC0642-1895) is in Healthy People
Healthy VolunteersUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of treatment emergent adverse events (TEAE)
From pre-dose (Day 1) to Day 66

Measured as number of events.

Secondary Endpoints

AUC0-∞; the area under the NNC0642-1895 serum concentration-time curve from time 0 to infinity after a single dose
From pre-dose (Day 1) to Day 66
Cmax; the observed maximum serum concentration of NNC0642-1895 after a single dose
From pre-dose (Day 1) to Day 66
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
NNC0642-1895EXPERIMENTALParticipants will be administered a single dose of NNC0537-1482 intravenously.
PlaceboPLACEBO_COMPARATORParticipants will receive placebo matched to NNC0642-1895 intravenously.

Interventions

NameTypeDescription
NNC0642-1895DRUGNNC0642-1895 will be administered intravenously.
PlaceboDRUGPlacebo will be administered intravenously.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-55 years (both inclusive) at the time of signing the informed consent. * Body Mass Index (BMI) between 18.5 to 29.9 kilogram per square meter (kg/m\^2) (both inclusive) at screening * Consider...

Countries:United States
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Recent Changes (Last 90 Days)

LOWSep 21, 2026NCT07829406NEW_TRIAL: changed
LOWSep 21, 2026NCT07829406NEW_TRIAL: changed

Frequently asked questions about NNC0642-1895

What is NNC0642-1895?

NNC0642-1895 is an investigational small molecule medicine being developed by Novo Nordisk A/S. It is in Phase 1 clinical development and is being studied in healthy volunteers, not in patients with a specific disease. It has not been approved by the FDA and remains an experimental compound.

Who makes NNC0642-1895?

NNC0642-1895 is being developed by Novo Nordisk A/S, which trades under the ticker NVO. Novo Nordisk is the sponsor of the clinical program evaluating the compound. No partner or licensing arrangement for this asset has been disclosed.

What phase is NNC0642-1895 in?

NNC0642-1895 is in Phase 1 development. One Phase 1 trial has been registered and is currently active, with no completed trials reported. The study is not yet recruiting participants. As a Phase 1 investigational drug, NNC0642-1895 has not received FDA approval.

What clinical trial is NNC0642-1895 in?

NNC0642-1895 is being evaluated in a single registered Phase 1 trial, NCT07829406, titled "A Study to See How Safe a New Medicine (NNC0642-1895) is in Healthy People." The trial is not yet recruiting, is planned to enroll 148 participants, and is being conducted in the United States.

How is the NNC0642-1895 trial designed?

The Phase 1 trial of NNC0642-1895, NCT07829406, is a randomized, double-blind, placebo-controlled study. It plans to enroll 148 healthy volunteers aged 18 years and older, with all sexes eligible. Participants are healthy volunteers rather than patients, and the study is being run at sites in the United States.