Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT05624580 | A Study to Look at Safety and Tolerability of NNC0582-0001, How it is Transported Throughout the Body and How it Works in Healthy Adults | PHASE1 | COMPLETED | 56 | — | — | Nov 15, 2022 | Oct 16, 2025 | Dec 24, 2025 | 1 | Austria |
Measured as number of events.
| Arm | Type | Description |
|---|---|---|
| Single Dose 1: NNC0582-0001 10 milligram (mg) | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 10 mg or matching placebo injection subcutaneously. |
| Single Dose 2: NNC0582-0001 30 mg | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 30 mg or matching placebo injection subcutaneously. |
| Single Dose 3: NNC0582-0001 90 mg | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 90 mg or matching placebo injection subcutaneously. |
| Single Dose 4: NNC0582-0001 250 mg | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 250 mg or matching placebo injection subcutaneously. |
| Single Dose 5: NNC0582-0001 600 mg | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 600 mg or matching placebo injection subcutaneously. |
| Single Dose 6: NNC0582-0001 1000 mg | EXPERIMENTAL | Participants will receive a single dose of NNC0582-0001 1000 mg or matching placebo injection subcutaneously. |
| Name | Type | Description |
|---|---|---|
| NNC0582-0001 | DRUG | Participants will receive single dose of any of the six dose levels of subcutaneous NNC0582-0001 in a sequential manner with the dose increasing between cohorts. |
| Placebo | DRUG | Participants will receive single dose of subcutaneous injection of placebo matched to NNC0582-0001. |
Inclusion Criteria: * Female of non-childbearing potential or male aged 18-55 years (both inclusive) at the time of signing informed consent. * Body Mass Index (BMI) from 20.0 to 30.0 kilogram per square meter (kg/m\^2) (both inclusive) at screening. * Considered to be generally healthy based on th...