Recent Updates
Recently added Catalysts

NNC0174 0833

Phase 1

Overweight and Obesity | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Nov 7, 2023

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05254158A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With ObesityPHASE1 COMPLETED 24Mar 3, 2022Sep 7, 2022Nov 7, 20231 China
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
AUC0-∞, NNC0174-0833: The area under the NNC0174-0833 plasma concentration-time curve from time 0 to infinity after a single dose
From pre-dose (Day 1) to Visit 7 (Day 36)

measured in h·nmol/L

Secondary Endpoints
AUC0-168, NNC0174-0833: The area under the NNC0174-0833 plasma concentration-time curve from time 0 to 168 hours after a single dose
From pre-dose (Day 1) to Visit 3 (Day 8)
Cmax, NNC0174-0833: The maximum concentration of NNC0174-0833 in plasma
From pre-dose (Day 1) to Visit 7 (Day 36)
tmax, NNC0174-0833: The time from dose administration to maximum plasma concentration of NNC0174-0833
From pre-dose (Day 1) to Visit 7 (Day 36)
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
NNC0174 0833 1.8 mgEXPERIMENTALEach participant will receive one single dose of NNC0174 0833
NNC0174 0833 0.9 mgEXPERIMENTALEach participant will receive one single dose of NNC0174 0833
NNC0174 0833 0.3 mgEXPERIMENTALEach participant will receive one single dose of NNC0174 0833
Interventions
NameTypeDescription
NNC0174 0833DRUGParticipants will either get a single dose of 0.3 mg, 0.9 mg or 1.8 mg NNC0174-0833, administered subcutaneously (s.c., under the skin)
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Key inclusion criteria * Chinese male subject aged 18-55 years (both inclusive) at the time of signing informed consent. * Body mass index (BMI) between 20.0 and 39.9 kg/m\^2 (both inclusive) at screening. * Body weight between 60.0 and 110.0 kg (both inclusive) at screening. Key exclusion criteri...

Countries:China
Unlock Eligibility Criteria