Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT03789578 | A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together | PHASE1 | COMPLETED | 30 | — | — | Jan 17, 2019 | Oct 10, 2019 | Nov 12, 2024 | 1 | Germany |
Measured in pmol\*h/L for insulin 287 following administration of a fixed ratio of NNC0148-0287sema and insulin 287.
Measured in pmol\*h/L for semaglutide following administration of a fixed ratio of NNC0148-0287sema and semaglutide.
| Arm | Type | Description |
|---|---|---|
| Semaglutide plus insulin 287 | EXPERIMENTAL | Participants will get a single dose of fixed-ratio combination of insulin 287 and semaglutide (NNC0148-0287sema (treatment C)). |
| Semaglutide alone | EXPERIMENTAL | Participants will get a single dose of semaglutide (treatment B) alone. |
| Insulin 287 alone | EXPERIMENTAL | Participants will get a single dose of insulin 287 (NNC0148-0287 (treatment A)) alone. |
| Name | Type | Description |
|---|---|---|
| NNC0148-0287sema | DRUG | Study staff will inject NNC0148-0287sema, 175unit (U)/0.5 mg in the morning after fasting under the skin of participants' thigh using a needle and a pen. |
| Semaglutide | DRUG | Study staff will inject semaglutide, 0.5 mg alone in the morning after fasting under the skin of participants' thigh using a needle and a pen. |
| NNC0148-0287 | DRUG | Study staff will inject insulin 287 (NNC0148-0287), 175U alone in the morning after fasting under the skin of participants' thigh using a needle and a pen. |
Inclusion Criteria: * Male or female, aged 18-64 years (both inclusive) at the time of signing informed consent * Diagnosed with type 2 diabetes mellitus more than or equal to 180 days prior to the day of screening * Body weight between 80.0 to 120.0 kg (both inclusive) * Glycosylated haemoglobin (...